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The response of the stream geomorphic index to fault activity is important for assessing the regional seismic hazard. The data used in this paper are 12 m resolution TanDEM-X data. The Fill tool in the Hydrology toolset in ArcGIS 10.5 was used to first process the digital elevation model (DEM), then analyse the flow direction of the DEM after filling and finally extract streams with catchment areas of more than 9 km2. Based on the DEM spatial analysis, the stream geomorphic index of the Lianfeng–Ningnan segment (LNS) of the Lianfeng fault was extracted, including the stream length gradient (SL) and the hypsometric integral (HI). This information, combined with the analysis of typical field geomorphology and terrace profiles, was used to define the fault activity period. To analyse the activity characteristics of the LNS, the LNS was divided into northern (Lianfeng to Jinyang), middle (Jinyang to Duiping town) and southern segments (Duiping town to Ningnan). The stream geomorphic index showed spatial variations, with mean SL and HI values of 384 and 0.45, respectively, in the northern segment; 175 and 0.41, respectively, in the middle segment; and 378 and 0.45, respectively, in the southern segment. These results indicate that the northern and southern segments of the LNS are more active than the middle segment, that there is little difference between the northern and southern segments, and that the activity of the middle segment is relatively weak. By comprehensively analysing the lithology, climate and tectonics in the LNS region, we conclude that tectonics are the main factor controlling the stream geomorphology in the LNS region. Based on this information and the analysis and dating of field geomorphology and terrace profiles, we found that the Lianfeng fault was active in the Holocene, which is consistent with the latest research results. [ABSTRACT FROM AUTHOR]