1. New amide alkaloids from Delphinium brunonianum.
- Author
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Zou YS, Dawa Z, Lin CZ, Zhang QY, Yao YF, Yuan Y, Zhu CC, and Wang ZY
- Subjects
- Alkaloids isolation & purification, Cholinesterase Inhibitors isolation & purification, Molecular Structure, Phytochemicals isolation & purification, Phytochemicals pharmacology, Tibet, Alkaloids pharmacology, Cholinesterase Inhibitors pharmacology, Delphinium chemistry, Plant Components, Aerial chemistry
- Abstract
Five new amide alkaloids, named delamide A-E (1-5), along with five known ones, methyl-N-(3-carboxy-2-methylpropanoyl) anthranilate (6), benzoic acid, 2-[(1-oxodecyl) amino]-methylester (7), puberline (8), benzoic acid, 2-[(4-methoxy-2-methyl-1, 4-dioxobutyl) amino]-methylester (9) and benzoic acid, 2-[(4-methoxy-3-methyl-1, 4-dioxobutyl) amino]-methylester (10) were isolated from the extract of Delphinium brunonianum. Their structures were elucidated by extensive spectroscopic analyses (including 1D-, 2D-NMR, and HR-ESI-MS). 1-10 were also evaluated for their acetylcholinesterase (AChE) inhibiting activity by the Ellman's method. Delamide A (1) showed highly selective AChE inhibition activity. The kinetic analysis revealed that 1 was a mixed-type reversible inhibitor of AChE., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2019
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