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Researchers at Tianjin Medical University in China have conducted a study on the role of hypoxia in esophageal squamous cell carcinoma (ESCC). They found that hypoxia promotes lactate accumulation in ESCC, which induces histone lysine lactylation (Kla) to regulate transcription. The researchers discovered that hypoxia facilitates histone H3K9la to enhance LAMC2 transcription, leading to the proliferation and invasion of ESCC. This study highlights the importance of histone Kla triggered by hypoxia in cancer. Further research is needed to explore the functional consequences of histone Kla in ESCC. [Extracted from the article]