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This paper examines the adoption and roll-out of a 100 Per Cent Condom Use Program (100% CUP) in the People's Republic of China (PRC). It first details the initial implementation of a 100% CUP in Thailand and explains how this created a framework for action in other developing countries. It then examines the implementation of pilot programs in China. We conclude that governmental authorities in the PRC now actively target designated high-risk populations such as female sex workers in order to combat the spread of sexually transmissible infections and HIV/AIDS. This has resulted in the introduction of new legal frameworks and the use of widespread media publicity to promote condom use and safer-sex strategies. However, the more effective implementation of a national 100% CUP in China requires attention to the problems associated with the legal and social marginalisation of female sex workers, which is reinforced by police-led crackdowns on prostitution. [ABSTRACT FROM AUTHOR]