1. Anti-proliferative activities of coumarins from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders. against human digestive tract carcinoma cell lines.
- Author
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Luo F, Sugita H, Muraki K, Saeki S, Chaipech S, Pongpiriyadacha Y, Muraoka O, and Morikawa T
- Subjects
- Antineoplastic Agents, Phytogenic isolation & purification, Apoptosis, Carcinoma drug therapy, Carcinoma pathology, Cell Line, Tumor, Coumarins isolation & purification, Flowers chemistry, Gastrointestinal Neoplasms drug therapy, Humans, Molecular Structure, Phytochemicals isolation & purification, Phytochemicals pharmacology, Plants, Medicinal chemistry, Thailand, Antineoplastic Agents, Phytogenic pharmacology, Coumarins pharmacology, Gastrointestinal Neoplasms pathology, Mammea chemistry
- Abstract
Geranylated coumarins named mammeasins G-J (1-4) were isolated from the methanol extract of the flowers of Mammea siamensis (Miq.) T. Anders. (Calophyllaceae) originating in Thailand. Their structures were established based on detailed spectroscopic analyses. The isolates, including previously reported coumarin constituents (5-28), exhibited anti-proliferative activities against human carcinoma cell lines HSC-2, HSC-4, MKN-45, and MCF-7. Mammeasin A (7, IC
50 = 13.6 μM) and surangin B (15, 15.2 μM), both consisting of the geranyl group, were found to show relatively strong activities against HSC-4 cells and their mechanisms of action were found to involve apoptotic cell death., (Copyright © 2020 Elsevier B.V. All rights reserved.)- Published
- 2021
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