1. Constituents of Fagraea fragrans with Antimycobacterial Activity in Combination with Erythromycin.
- Author
-
Madmanang S, Cheyeng N, Heembenmad S, Mahabusarakam W, Saising J, Seeger M, Chusri S, and Chakthong S
- Subjects
- Anti-Bacterial Agents chemistry, Iridoids chemistry, Isocoumarins chemistry, Microbial Sensitivity Tests, Molecular Structure, Mycobacterium smegmatis drug effects, Nuclear Magnetic Resonance, Biomolecular, Plant Bark chemistry, Staphylococcus aureus drug effects, Thailand, Anti-Bacterial Agents isolation & purification, Anti-Bacterial Agents pharmacology, Erythromycin pharmacology, Iridoids isolation & purification, Iridoids pharmacology, Isocoumarins isolation & purification, Isocoumarins pharmacology
- Abstract
Seven new compounds constituted by three secoiridoids (1-3), two isocoumarins (4 and 5), an iridoid (6), and an aromatic derivative (7) in addition to 24 known compounds were isolated from the stem bark of Fagraea fragrans. The structures of the new compounds were determined on the basis of spectroscopic data analysis. The isolated compounds showed no antibacterial activity against Staphylococcus aureus and Escherichia coli. However, 5-formylisochromen-1-one (4), (-)-mellein (8), and swermacrolactone C (9) exhibited potent antimycobacterial activities against Mycobacterium smegmatis when used in combination with the antibiotic drug erythromycin.
- Published
- 2016
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