1. Anti-inflammatory potential of a Thai traditional remedy called Prabchompoothaweep in an animal model of acute and sub-acute inflammation.
- Author
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Chansiw, Nittaya, Chusri, Pattranuch, Praman, Siwaporn, Hawiset, Thaneeya, Sukhorum, Wannisa, Champakam, Sorraya, and Charoensup, Rawiwan
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BIOLOGICAL models , *CYTOKINES , *MEDICINAL plants , *INFLAMMATION , *ANIMAL experimentation , *TRADITIONAL medicine , *RATS , *DESCRIPTIVE statistics , *PLANT extracts , *EDEMA - Abstract
Prabchompoothaweep (PCT) is a Thai remedy which is composed of 23 herbs and has been added onto the National List of Essential Medicines (NLEM) of Thailand. This remedy has been used to treat allergic rhinitis and asthma in Thai traditional medicine for many years. Furthermore, a few studies have reported anti-allergic, anti-malarial, anti-inflammatory and antioxidant activities. This study aims to evaluate anti-inflammatory activity of PCT extract in an animal model. The animal model of acute inflammation was studied over a 24-h period, utilizing the method of carrageenan-induced paw oedema. In addition, sub-acute inflammation was examined over 7 days, using the formalin-induced paw oedema method. The treatment groups received PCT extracts, via the oral route, at 1-h prior to injection and then the sub plantar of the rat right paw was injected with the named substances to generate paw oedema. The paw thickness was measured by vernier caliper at regular intervals after injection. At the end of experiment, the blood and paw tissues were collected for measurement of pro-inflammatory cytokines and histological examination respectively. In acute inflammation, all doses of PCT extract (250, 500 and 1000 mg/kg p.o.) significantly reduced paw thickness after the first 3 h in a dose-dependent manner and the percentage of inhibition was 38.7%, 47.8% and 49.5% respectively. The pro-inflammatory cytokines, including TNF-α and IL-1β, statistically decreased with all doses of the extracts. However, the histological examination did not reveal significant results due to the short time duration. As regards to sub-acute inflammation, all doses of PCT extract significantly reduced paw thickness with 12.78%, 23.64% and 35.78%, in a dose dependent manner. Also, the pro-inflammatory cytokines (TNF-α and IL-1β) significantly decreased at day 7. Interestingly, the histological examination of paw tissue demonstrated reductions of mononuclear infiltrations of inflammatory cells, this was observed in the group receiving PCT extracts, also in a dose-dependent manner. Therefore, PCT exerted anti-inflammatory activity in an animal model of acute and sub-acute inflammation, suggesting that it could be used as a new source for treatment of inflammatory diseases. [Display omitted] • Prabchompoothaweep (PCT), a Thai remedy, is used to treat allergic rhinitis and asthma in Thai traditional medicine and has anti-inflammatory potential. • PCT exerts anti-inflammatory activity by reducing paw thickness and pro-inflammatory cytokines in acute and sub-acute inflammation. • PCT reduces mononuclear infiltrations in paw tissue, which have been observed only in the sub-acute inflammatory model. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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