1. A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: differences among racial/ethnic groups.
- Author
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Tortolero-Luna G, Mitchell MF, Swan DC, Tucker RA, Wideroff L, and Icenogle JP
- Subjects
- Adult, Case-Control Studies, Female, Humans, Papillomavirus Infections diagnosis, Prevalence, Risk Factors, Socioeconomic Factors, Texas epidemiology, Tumor Virus Infections diagnosis, Uterine Cervical Neoplasms diagnosis, Uterine Cervical Dysplasia diagnosis, Black or African American, Black People, Hispanic or Latino statistics & numerical data, Papillomaviridae, Papillomavirus Infections ethnology, Tumor Virus Infections ethnology, Uterine Cervical Neoplasms ethnology, White People, Uterine Cervical Dysplasia ethnology
- Abstract
We conducted a case-control study of the association between SIL and HPV among whites (W), African Americans (AA), and Hispanics (H) in Harris County, Texas. Cases were identified at M.D. Anderson Cancer Center Colposcopy Clinic. Controls were identified among women obtaining routine Pap screening at two Harris County Health Department Clinics. HPV was detected by a PCR-based fluorescent assay. Dichotomous and polytomous logistic regression models were used to estimate adjusted odd ratios (AOR) and 95% confidence intervals (CI) for SIL among racial/ethnic groups and grade of disease. Prevalence of HPV infection was 64% in low grade SIL (LSIL), 84% in high grade SIL (HSIL), and 19% in controls. Risk of SIL was higher in H than in W and AA, AOR 29.5 (12.4-70.5), 15.3 (6.0-33.8), and 5.8 (2.6-12.6), respectively. Similarly, racial/ethnic differences were observed for both LSIL (AOR = 16.6, 7.7, and 4.3, respectively) and HSIL (AOR = 78.6, 34.6, and 14.2, respectively). Findings support the association between SIL and HPV and differences in the strength of the association with LSILs and HSILs. Data also suggest a higher risk for H and a lower risk for AA.
- Published
- 1998
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