1. Safety and Efficacy of Immune Checkpoint Inhibitors in Patients with Cancer and Viral Hepatitis: The MD Anderson Cancer Center Experience.
- Author
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Nardo, Mirella, Yilmaz, Bulent, Nelson, Blessie Elizabeth, Torres, Harrys A, Wang, Lan Sun, Granwehr, Bruno Palma, Song, Juhee, Pria, Hanna R F Dalla, Trinh, Van A, Oliva, Isabella C Glitza, Patel, Sapna P, Tannir, Nizar M, Kaseb, Ahmed Omar, Altan, Mehmet, Lee, Sunyoung S, Miller, Ethan, Zhang, Hao, Stephen, Bettzy A, and Naing, Aung
- Subjects
DRUG efficacy ,HEPATITIS B ,PATIENT aftercare ,IMMUNE checkpoint inhibitors ,SPECIALTY hospitals ,CONFIDENCE intervals ,VIRAL hepatitis ,RETROSPECTIVE studies ,DISEASE incidence ,HEPATITIS C ,ANTIVIRAL agents ,TREATMENT duration ,CANCER treatment ,CANCER patients ,DESCRIPTIVE statistics ,RESEARCH funding ,TUMORS ,DRUG side effects ,PATIENT safety ,EVALUATION - Abstract
Background Despite the clinical benefit of immune checkpoint inhibitors (ICIs), patients with a viral hepatitis have been excluded from clinical trials because of safety concerns. The purpose of this study was to determine the incidence rate of adverse events (AEs) in patients with viral hepatitis who received ICIs for cancer treatment. Materials and Methods We conducted a retrospective study in patients with cancer and concurrent hepatitis B or C, who had undergone treatment with ICI at MD Anderson Cancer Center from January 1, 2010 to December 31, 2019. Results Of the 1076 patients screened, we identified 33 with concurrent hepatitis. All 10 patients with HBV underwent concomitant antiviral therapy during ICI treatment. Sixteen of the 23 patients with HCV received it before the initiation of ICI. The median follow-up time was 33 months (95% CI, 23-45) and the median duration of ICI therapy was 3 months (IQR, 1.9-6.6). Of the 33 patients, 12 (39%) experienced irAEs (immune-related adverse events) of any grade, with 2 (6%) having grade 3 or higher. None of the patients developed hepatitis toxicities. Conclusion ICIs may be a therapeutic option with an acceptable safety profile in patients with cancer and advanced liver disease. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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