1. [Brain neurotransmitter systems gene Polymorphism: the Search for pharmacogenetic markers of efficacy of haloperidol in Russians and Tatars].
- Author
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Gareeva AE, Kinyasheva KO, Galaktionova DY, Sabirov ET, Valinourov RG, Chudinov AV, Zasedatelev AS, Nasedkina TV, and Khusnutdinova EK
- Subjects
- Adolescent, Adult, Antipsychotic Agents therapeutic use, Brain drug effects, Brain metabolism, Case-Control Studies, Catechol O-Methyltransferase genetics, Female, Haloperidol therapeutic use, Humans, Male, Middle Aged, Receptor, Serotonin, 5-HT2A genetics, Receptors, Dopamine D4 genetics, Schizophrenia drug therapy, Schizophrenia ethnology, Tatarstan, Tryptophan Hydroxylase genetics, Vesicular Monoamine Transport Proteins, Antipsychotic Agents pharmacology, Haloperidol pharmacology, Polymorphism, Single Nucleotide, Schizophrenia genetics, Synaptic Transmission genetics
- Abstract
Antipsychotics are the main drugs for the treatment of severe mental illness--schizophrenia affects about 1% of the population. The mechanism of action of neuroleptics is still up to the end. Several studies in the field of pharmacogenetics confirm enourmous influence of several neurotransmitter systems in the brain on the efficiency and the development of side effects. In this paper, we analyzed the association of nine polymorphic variants of five genes of dopaminergic and serotonergic systems DRD4, HTR2A, TPH1, SLC18A1, COMT in Russian and Tatars patients living in the Republic of Bashkortostan (RB) with the efficiency of a typical antipsychotic haloperidol on the scale of positive and negative systems of PANSS. The study established pharmacogenetic markers of increased and decreased effectiveness of therapy with haloperidol in the treatment groups. The results of this study confirm the importance of changes in the nucleotide sequences of the studied genes of the serotoninergic and dopaminergic systems (HTR2A, TPH1, SLC18A1 COMT, DRD4) in the formation of individual sensitivity to haloperidol. The results of our work considered as preliminary contact, requires an increase in the number of samples studied.
- Published
- 2015
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