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An assessment of the health indicators of young people in Uzbekistan was carried out based on the results of immunological screening - determining the quantitative content of antigen-binding lymphocytes (ASL), sensitized to tissue antigens (TA) of various organs. For a comparative study, male and female volunteers aged 18-25 years old living in Tashkent city of the Tashkent region (northern region) and in the city of Termez of the Surkhandarya region (southern region) of Uzbekistan was examined. Consequently, in the southern region of Uzbekistan (Termez), the frequency of manifestation of pathological processes in various organs is relatively higher than in the northern region (Tashkent). [ABSTRACT FROM AUTHOR]