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The western Kunlun thrust belt defines the boundary between the stable Tarim Basin in the north and the intensely deformed Cenozoic Tibetan Plateau in the south. Because of its important tectonic position, understanding its tectonic evolution should have important implications for propagation of deformation from Tibet to its neighboring cratonal regions during India-Eurasia convergence. We here present new structural analyses based on field investigations and seismic reflection profiles across the Hotan-Tiklik segment of the western Kunlun thrust belt. The results indicate that the structural section crosses two major thrust zones: the Tiklik zone in the hinterland to the south and the Hotan zone in the foreland to the north. Within these, the Hotan thrust zone is thin skinned, with its deformation characterized by fault-bend folding and fault slipping along detachment layers, whereas the Tiklik thrust zone involves basement, with its deformation driven by the currently steeply dipping Tiklik fault. Results from apatite fission track thermochronology in combination with growth strata and balanced cross section indicate that the Hotan-Tiklik segment underwent two-stage deformation: (1) development of the Tiklik thrust during the late Oligocene–early Miocene and again since the mid- to late Miocene and (2) activity of the Hotan thrust since the mid- to late Miocene as a result of basinward propagation of thrusting. The balanced cross section, combined with the apatite fission track results, suggests that the Hotan-Tiklik segment contributes a total shortening magnitude of more than ca. 34 ± 6 km. Within this, ca. 4 ± 2 and ca. 23 ± 1 km of the shortenings were absorbed by the Hotan anticline and the Hotan detachment fault, respectively, both of which were related to detachment layers. This suggests that detachment layers played an efficient role in propagating deformation from the western Tibetan Plateau into the Tarim Basin. [ABSTRACT FROM AUTHOR]