1. In vitro susceptibility of P. falciparum populations from Colombia and Tanzania to a new synthetic peroxide (OZ277).
- Author
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Osorio L, Murillo C, Aponte S, Mayagaya V, Scheurer C, Brun R, Matile H, and Wittlin S
- Subjects
- Animals, Child, Child, Preschool, Colombia, Humans, Infant, Inhibitory Concentration 50, Plasmodium falciparum growth & development, Plasmodium falciparum isolation & purification, Tanzania, Antimalarials pharmacology, Heterocyclic Compounds, 1-Ring pharmacology, Malaria, Falciparum parasitology, Peroxides pharmacology, Plasmodium falciparum drug effects, Spiro Compounds pharmacology
- Abstract
Sensitivity of Plasmodium falciparum populations from Colombia (N = 38) and Tanzania (N = 45) to the newly developed, fully synthetic peroxide OZ277 was investigated using a standard isotopic microtest. OZ277 showed excellent activity against chloroquine-resistant isolates in Colombia with median IC(50) [range] values of 2.5 ng/mL [0.34-8] (4.4 nM [0.6-14]) and Tanzania with 1.5 ng/mL [0.22-10] (2.65 nM [0.4-17.7]). The potency of OZ277 was similar to artesunate, showing median IC(50) values of 1.5 ng/mL [0.42-8.6] (3.8 nM [1.1-22.3]) and 1.8 ng/mL [0.2-10] (4.7 nM [0.5-26.04]) in Colombia and Tanzania, respectively. These results support the development of this new antimalarial compound.
- Published
- 2007