1. Combined effects of GSTO1 and SULT1A1 polymorphisms and cigarette smoking on urothelial carcinoma risk in a Taiwanese population.
- Author
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Tung MC, Wang YH, Yeh SD, Wu CC, Chen KC, Huang ZM, Huang MT, and Chiou HY
- Subjects
- Aged, Arylsulfotransferase metabolism, Carcinoma, Transitional Cell epidemiology, Carcinoma, Transitional Cell pathology, Female, Genotype, Glutathione Transferase metabolism, Humans, Male, Middle Aged, Odds Ratio, Polymerase Chain Reaction, Risk Factors, Taiwan epidemiology, Urologic Neoplasms epidemiology, Urologic Neoplasms pathology, Arylsulfotransferase genetics, Carcinoma, Transitional Cell genetics, DNA, Neoplasm genetics, Glutathione Transferase genetics, Polymorphism, Genetic, Smoking adverse effects, Urologic Neoplasms genetics
- Abstract
Background/purpose: Cigarette smoking is the main risk factor for urothelial carcinoma of the bladder (UCB). Glutathione S-transferase omega 1 (GSTO1) and sulfotransferase 1A1 (SULT1A1) have been reported to be associated with the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. The aim of the present study was to investigate the combined effects of polymorphisms in GSTO1 and SULT1A1 genes and cigarette smoking on UCB risk in a Taiwanese population., Methods: A total of 300 patients with histopathologically confirmed UCB and 233 cancer-free controls were recruited from the Department of Urology of Tung's Taichung Metro Harbor Hospital and Taipei Medical University Hospital. A comprehensive interview was conducted to collect personal information, including demographic characteristics and cigarette smoking status. A multivariate-adjusted logistic regression was performed to estimate the risk of UCB., Results: A significantly increased risk of UCB was observed in ever smokers [odds ratio (OR) = 2.3]. The Ala/Ala genotype of the GSTO1 gene and the Arg/Arg genotype of the SULT1A1 gene were associated with a significantly increased risk of UCB, with ORs of 1.8 [95% confidence interval (CI) = 1.2-2.6] and 2.1 (95% CI = 1.6-4.5), respectively. Significantly increased UCB risks were found in heavy smokers with the Ala/Ala genotype of the GSTO1 gene (OR = 4.2) and the Arg/Arg genotype of the SULT1A1 gene (OR = 6.8). Furthermore, a significant synergistic effect in an additive model (OR = 3.5) between the GSTO1 Ala/Ala genotype and the SULT1A1 Arg/Arg genotype on UCB risk was observed., Conclusion: The present study provided epidemiological evidence for a significantly increased risk of UCB in ever smokers with the Ala/Ala genotype of the GSTO1 gene and the Arg/Arg genotype of the SULT1A1 gene., (Copyright © 2012. Published by Elsevier B.V.)
- Published
- 2014
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