1. New cytotoxic cembranolides from the soft coral Lobophytum michaelae.
- Author
-
Wang SK and Duh CY
- Subjects
- Animals, Antineoplastic Agents chemistry, Antineoplastic Agents isolation & purification, Antiviral Agents chemistry, Antiviral Agents isolation & purification, Cell Line, Tumor, Cytomegalovirus drug effects, Diterpenes chemistry, Diterpenes isolation & purification, Drug Discovery, Humans, Inhibitory Concentration 50, Lactones chemistry, Lactones isolation & purification, Lactones pharmacology, Marine Toxins chemistry, Marine Toxins isolation & purification, Mice, Molecular Structure, Neoplasms drug therapy, Pacific Ocean, Stereoisomerism, Taiwan, Anthozoa chemistry, Antineoplastic Agents pharmacology, Antiviral Agents pharmacology, Diterpenes pharmacology, Marine Toxins pharmacology
- Abstract
Six new cembranolides, michaolides L-Q (1-6), and a known cembranolide, lobomichaolide (7) were isolated from the CH₂Cl₂ extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1-7 and their cytotoxicity against selected cell lines were evaluated.
- Published
- 2012
- Full Text
- View/download PDF