1. Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese.
- Author
-
Tan EK, Lu CS, Peng R, Teo YY, Wu-Chou YH, Chen RS, Weng YH, Chen CM, Fung HC, Tan LC, Zhang ZJ, An XK, Lee-Chen GJ, Lee MC, Fook-Chong S, Burgunder JM, Wu RM, and Wu YR
- Subjects
- Adolescent, Adult, Age of Onset, Aged, Aged, 80 and over, Asian People ethnology, Asian People genetics, Female, Genetic Association Studies, Humans, Male, Middle Aged, Parkinson Disease epidemiology, Singapore epidemiology, Singapore ethnology, Taiwan epidemiology, Taiwan ethnology, Ubiquitination genetics, Young Adult, Genetic Variation genetics, Parkinson Disease enzymology, Parkinson Disease genetics, Ubiquitin Thiolesterase genetics
- Abstract
The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD., (Copyright © 2008 Elsevier Inc. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF