1. Biological monitoring for occupational acrylamide exposure from acrylamide production workers.
- Author
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Huang YF, Wu KY, Liou SH, Uang SN, Chen CC, Shih WC, Lee SC, Huang CC, and Chen ML
- Subjects
- Acrylamide analysis, Acrylamides urine, Adult, Female, Half-Life, Humans, Inhalation Exposure analysis, Male, Maximum Allowable Concentration, Middle Aged, Skin Absorption, Spectrometry, Mass, Electrospray Ionization, Taiwan, Tandem Mass Spectrometry, Acrylamide pharmacokinetics, Air Pollutants, Occupational analysis, Environmental Monitoring methods, Occupational Exposure analysis
- Abstract
Objective: We conducted a repeated-measurement study to (1) investigate the correlation between occupational exposure to airborne acrylamide (AA) and the time-dependent behavior of urinary AAMA, GAMA2, and GAMA3 and (2) calculate the estimated biological exposure index at the permissible exposure limit (PEL) level of 30 μg/m(3)., Methods: Forty-four workers were recruited--8 were AA-exposed and 36 were controls. Pre- and post-shift urine samples were collected from the exposed group in parallel with personal sampling for 8 consecutive days and only 1 day for the control group and analyzed using liquid chromatography-electrospray ionization/tandem mass spectrometry (LC-ESI-MS/MS)., Results: Post-shift urinary AAMA level was significantly associated with personal AA exposure (p < 0.001), indicating that urinary AAMA was a better AA exposure biomarker. The estimated urinary excretion of AAMA was 3.0 mg/g creatinine for nonsmoking workers exposed to the PEL of 30 μg/m(3). The median GAMA (the sum of GAMA2 and GAMA3)/AAMA ratio for exposed workers was 0.03 (range, 0.005-0.14), relatively lower than that of the nonoccupational group., Conclusions: Although sample size in this study was small, the repeated-measurement data provide useful reference for future studies related to biological monitoring of occupational exposure to AA.
- Published
- 2011
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