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Introduction: Previous studies have revealed the significant influence of electronic devices, especially social media use, on sleep difficulties among adolescents. In this study, disturbed sleep due to social media use (DSSM) was defined as reduced or troubled sleep caused by nighttime-specific behaviors such as waking to check updates, being notified by incoming messages, or postponed bedtime because of social media activities. Inadequate and disturbed sleep during youth interferes with daytime academic efficiency and may be associated with school burnout, which were examined in this study., Methods: Using two data waves collected from questionnaires on school burnout and DSSM and school test scores of 2462 Taiwanese middle school students (52.5% males) from various school types with average ages of 13.9 (SD = 0.72) and 14.3 (SD = 0.66) at Time 1 and Time 2, we investigated the relationship between the variables across time., Results: DSSM, academic performance, and school burnout were significantly correlated. Cross-lagged analyses to the group of adolescents with higher than the average DSSM scores revealed that burnout predicted lower academic achievements through DSSM as a mediator. Burnout did not have a direct effect on school performance but influenced the latter through disturbed sleep. Poor academic achievement in its turn showed a feedback effect on higher levels of burnout., Conclusions: This research reveals a vicious cycle of burnout, disturbed sleep, and academic achievement. During adolescence, school burnout through DSSM increase can lead to a lower academic performance that may later cause even higher burnout., (Copyright © 2020 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.)