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Rationale, aims and objectives: Pressure ulcers may have severe impacts on the quality of life of patients, including pain, low mood and restrictions in performing daily life and social life activities. In Switzerland, 4% of patients develop hospital‐acquired pressure ulcers. Six hospitals teamed up with the Vaud Hospital Federation (Switzerland) in a Breakthrough Collaborative, with the goal of reducing hospital‐acquired pressure ulcers by 50%. The aim of this study was to assess the actual reduction. Methods: A multimodal set of interventions was deployed in all wards except obstetrics and gynaecology, over 18 months starting in October 2016, including systematic risk assessment, use of a prevention bundle, education through e‐learning, measurement and feedback, patient engagement and promotion of a safety culture. All six hospitals monitored compliance with the use of the risk assessment, bundle application and patient involvement aspects. A safety calendar was implemented in all wards, for recording and visually displaying the numbers of new patients with pressure ulcers, as well as the presence of such ulcers upon admission and their category. Results: Compliance with performing Braden risk assessments rose from 39% at baseline to 61% by the end of the collaborative (P <.001), prevention bundle compliance from 2% to 30% (P <.001%) and documented patient engagement from 2% to 21% (P <.001%). The percentage of days where one or more patient was reported as having developed one or more pressure ulcers in the ward decreased from 8.21% to 4.18%, a 49% reduction (P <.001) which amounts to preventing 1124 new patients from developing one or more pressure ulcers during the collaborative. Conclusions: The Breakthrough Collaborative using a multimodal improvement approach combined with measurement and feedback was associated with a statistically and clinically significant improvement in compliance to best practice and with a reduction of hospital‐acquired pressure ulcers by half. [ABSTRACT FROM AUTHOR]