1. Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.
- Author
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Power RA, Steinberg S, Bjornsdottir G, Rietveld CA, Abdellaoui A, Nivard MM, Johannesson M, Galesloot TE, Hottenga JJ, Willemsen G, Cesarini D, Benjamin DJ, Magnusson PK, Ullén F, Tiemeier H, Hofman A, van Rooij FJ, Walters GB, Sigurdsson E, Thorgeirsson TE, Ingason A, Helgason A, Kong A, Kiemeney LA, Koellinger P, Boomsma DI, Gudbjartsson D, Stefansson H, and Stefansson K
- Subjects
- Cohort Studies, Female, Humans, Iceland epidemiology, Male, Middle Aged, Netherlands epidemiology, Risk, Sweden epidemiology, Bipolar Disorder genetics, Creativity, Genetic Predisposition to Disease genetics, Multifactorial Inheritance genetics, Psychotic Disorders genetics, Registries, Schizophrenia genetics
- Abstract
We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10(-6) and 3.8 × 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.
- Published
- 2015
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