Search

Your search keyword '"Corrales, E."' showing total 1 results
Start Over Author "Corrales, E." Region sweden

Refine your results

1 results on '"Corrales, E."'

1. Calibrated serological techniques demonstrate significant different serum response rates to an oral killed cholera vaccine between Swedish and Nicaraguan children.

Author

Hallander HO, Paniagua M, Espinoza F, Askelöf P, Corrales E, Ringman M, and Storsaeter J

Subjects
Administration, Oral, Calibration, Child, Child, Preschool, Cholera Vaccines administration & dosage, Clinical Trials as Topic, Double-Blind Method, Enzyme-Linked Immunosorbent Assay, Female, Humans, Infant, Male, Nicaragua, Safety, Serologic Tests, Sweden, Vaccines, Inactivated administration & dosage, Antibodies, Bacterial biosynthesis, Cholera Vaccines immunology, Vaccination, Vaccines, Inactivated immunology, Vibrio cholerae immunology
Abstract

Serum responses to oral cholera vaccines were assessed in three paediatric vaccine trials, two in León, Nicaragua and one in Stockholm, Sweden. A calibrated anti-cholera toxin B subunit (CTB) IgA ELISA was used together with an assay for vibriocidal antibodies. Swedish children had lower pre-vaccination levels of antibody, but serum responses were more pronounced in Swedish children than in Nicaraguan children. Post-vaccination levels of anti-toxin antibody were generally above those found after natural infections with enterotoxigenic Escherichia coli, that cross-reacts serologically with Vibrio cholerae. Adverse events seen after vaccination were generally mild and of little clinical significance.

Published
2002
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results