1. Physical training after percutaneous coronary intervention in patients with stable angina: effects on working capacity, metabolism, and markers of inflammation.
- Author
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Astengo M, Dahl A, Karlsson T, Mattsson-Hultén L, Wiklund O, and Wennerblom B
- Subjects
- Aged, Angina Pectoris immunology, Angina Pectoris metabolism, Angina Pectoris physiopathology, Apolipoprotein A-I blood, Apolipoproteins B blood, Biomarkers blood, Blood Glucose metabolism, C-Reactive Protein metabolism, Coronary Disease immunology, Coronary Disease metabolism, Coronary Disease physiopathology, Female, Glycated Hemoglobin metabolism, Humans, Interleukin-10 blood, Interleukin-6 blood, Interleukin-8 blood, Lipids blood, Male, Middle Aged, Serum Amyloid A Protein metabolism, Sweden, Time Factors, Treatment Outcome, Angina Pectoris therapy, Angioplasty, Balloon, Coronary, Coronary Disease therapy, Energy Metabolism, Exercise Therapy, Exercise Tolerance, Home Care Services, Inflammation Mediators blood
- Abstract
Objective: Physical activity is effective in primary and secondary prevention of cardiovascular disease. In this study, we tested the hypothesis that exercise training improves glucose and lipid metabolism, the inflammatory/anti-inflammatory balance, and the outcome of elective percutaneous coronary intervention (PCI) in patients with stable coronary disease., Methods: Sixty-two patients scheduled to undergo PCI for stable angina were randomized to intensive physical activity (n=33) consisting of home-based exercise on a bicycle ergometer or maintain their usual sedentary life (n=29). The training program started 2 months before PCI and terminated 6 months afterwards. Clinical examination, blood sampling (fasting glucose, glycated hemoglobin, lipid profile, apolipoprotein B, apolipoprotein A1, C-reactive protein, serum amyloid A, interleukin-6, interleukin-8, and interleukin-10), and maximal exercise tests were performed at inclusion, 1 week before PCI, and 3 and 6 months afterwards., Results: Fifty-six patients [28 per group, 45 men, mean age 63 (SD 7.8) years] completed the follow-up. According to self-reports, patients in the training group exercised more often and longer [4.9 (SD 1.1) vs. 0.6 (SD 1.3) days/week, 36 (SD 12) vs. 15 (SD 31) min/session, P<0.0001]. Improvement in maximal exercise capacity was significantly better in the training group [27 (SD 27) vs. 9 (SD 27) W, P=0.02]. Exercise had no significant effects on glucose and lipid metabolism, plasma cytokines, or acute-phase reactants., Conclusion: A home-based training program significantly improved maximal exercise capacity but did not affect glucose or lipid metabolism or markers of inflammation.
- Published
- 2010
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