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2 results on '"Vascular Diseases metabolism"'

1. Subcutaneous advanced glycation end-products and lung function according to glucose abnormalities: The ILERVAS Project.

Author

Sánchez E, Lecube A, Betriu À, Hernández C, López-Cano C, Gutiérrez-Carrasquilla L, Kerkeni M, Yeramian A, Purroy F, Pamplona R, Farràs C, Fernández E, Barbé F, Simó R, Hernández M, Rius F, Polanco D, de la Torre MS, Torres G, Godoy P, Portero-Otin M, Jové M, Colàs-Compàs L, Benabdelhak I, Miquel E, Ortega M, Valdivielso JM, Bermúdez M, and Martínez-Alonso M

Subjects
Aged, Asymptomatic Diseases, Case-Control Studies, Diabetes Mellitus, Type 2 metabolism, Diabetes Mellitus, Type 2 physiopathology, Early Diagnosis, Female, Glucose Metabolism Disorders complications, Glycation End Products, Advanced analysis, Humans, Kidney Diseases diagnosis, Kidney Diseases metabolism, Male, Middle Aged, Optical Imaging, Prediabetic State metabolism, Prediabetic State physiopathology, Respiratory Function Tests, Skin diagnostic imaging, Spain, Vascular Diseases diagnosis, Vascular Diseases metabolism, Glucose Metabolism Disorders metabolism, Glucose Metabolism Disorders physiopathology, Glycation End Products, Advanced metabolism, Lung physiology, Skin metabolism
Published
2019
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2. Tissue distribution of hyalinazing vasculopathy lesions in peritoneal dialysis patients: an autopsy study.

Author

Jiménez-Heffernan JA, Perna C, Auxiliadora Bajo M, Luz Picazo M, Del Peso G, Aroeira L, Aguilera A, Tejerina E, López-Cabrera M, and Selgas R

Subjects
Aged, Autopsy, Calcinosis etiology, Female, Fibrosis, Humans, Male, Middle Aged, Risk Factors, Severity of Illness Index, Spain, Uremia complications, Uremia pathology, Vascular Diseases etiology, Vascular Diseases metabolism, Calcinosis pathology, Hyalin metabolism, Peritoneal Dialysis adverse effects, Peritoneum blood supply, Vascular Diseases pathology
Abstract

Uremia is considered capable of inducing structural anomalies of the peritoneum, including hyalinizing vasculopathy (HV). To further elucidate the contribution of uremia to the severity of HV, we performed an autopsy study of peritoneal dialysis (PD) patients with severe peritoneal HV lesions. Uremia is a systemic condition and, if capable of inducing HV, it will be expected to be detected outside the peritoneum. Seven autopsy cases of PD patients showing prominent peritoneal HV lesions were selected. Histological slides from the peritoneum, abdominal organs, heart and pericardium, lungs, visceral pleura, and central nervous system were reviewed. Peritoneal lesions were intense in all patients with prominent HV, fibrosis, and a variable presence of inflammation, fibrin, and calcification. Except for focal HV lesions in the intestinal submucosa of one diabetic patient, HV lesions were limited to the peritoneal membrane. None of the other extraperitoneal tissues showed such lesions. In conclusion, extraperitoneal vessels of PD patients show no relevant HV lesions when compared to peritoneal ones. This observation suggests that PD-related factors are the main contributors to the severity of vasculopathy. Uremia may participate in the development of the lesion but it does not seem to be responsible for its severity.

Published
2008
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