1. Multidisciplinary consensus on optimising the detection of NTRK gene alterations in tumours.
- Author
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Garrido P, Hladun R, de Álava E, Álvarez R, Bautista F, López-Ríos F, Colomer R, and Rojo F
- Subjects
- Adult, Age Factors, Benzamides therapeutic use, Child, High-Throughput Nucleotide Sequencing, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Indazoles therapeutic use, Molecular Targeted Therapy, Neoplasms diagnosis, Neoplasms therapy, Oncogene Proteins, Fusion analysis, Protein Kinase Inhibitors therapeutic use, Pyrazoles therapeutic use, Pyrimidines therapeutic use, Reverse Transcriptase Polymerase Chain Reaction, Societies, Medical, Spain, Consensus, Membrane Glycoproteins genetics, Neoplasms genetics, Oncogene Proteins, Fusion genetics, Receptor, trkA genetics, Receptor, trkB genetics, Receptor, trkC genetics
- Abstract
The recent identification of rearrangements of neurotrophic tyrosine receptor kinase (NTRK) genes and the development of specific fusion protein inhibitors, such as larotrectinib and entrectinib, have revolutionised the diagnostic and clinical management of patients presenting with tumours with these alterations. Tumours that harbour NTRK fusions are found in both adults and children; and they are either rare tumours with common NTRK fusions that may be diagnostic, or more prevalent tumours with rare NTRK fusions. To assess currently available evidence on this matter, three key Spanish medical societies (the Spanish Society of Medical Oncology (SEOM), the Spanish Society of Pathological Anatomy (SEAP), and the Spanish Society of Paediatric Haematology and Oncology (SEHOP) have brought together a group of experts to develop a consensus document that includes guidelines on the diagnostic, clinical, and therapeutic aspects of NTRK-fusion tumours. This document also discusses the challenges related to the routine detection of these genetic alterations in a mostly public Health Care System.
- Published
- 2021
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