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Objectives To assess agreement between the 2021 Definition Of Remission In SLE (DORIS) and physician-judged lupus activity. Methods A cross-sectional analysis was conducted of data from a Spanish prospective multicentre study of SLE patients. We applied the 2021 DORIS criteria and assessed whether remission status based on this definition agreed with remission as per physician clinical judgement and reasons for disagreement between them. Results Out of 508 patients [92% women; mean age (s. d.): 50.4 years (13.7)] studied, 267 (54.4%) met the criteria for 2021 DORIS remission. Based on physicians' judgement, 277 (55.9%) patients were classified as in remission or serologically active clinically quiescent (SACQ). The overall rate of agreement between these assessments was 81.2% (95% CI: 79.9, 82.9%) with a Cohen's kappa of 0.62 (0.55–0.69). Overall, 46 (9.1%) patients were classified as in remission/SACQ by rheumatologists but did not meet the 2021 DORIS criteria for remission. The main reasons for discrepancies were a clinical SLE Disease Activity Index (cSLEDAI) score >0 in 39 patients, a Physician Global Assessment score >0.5 in five patients, and prednisone >5 mg/day in another five patients. Conclusions The 2021 DORIS remission is an achievable target in clinical practice. There is substantial agreement between the DORIS definition and physician-judged remission. The discordance was mainly due to physicians classifying some patients with ongoing mild disease activity as in remission. Thus, the standardized DORIS definition should be used to define the target in a treat-to-target strategy for the management of SLE. [ABSTRACT FROM AUTHOR]

Objectives To apply the lupus low disease activity state (LLDAS) definition within a large cohort of patients and to assess the agreement between the LLDAS and the physician's subjective evaluation of lupus activity. Methods We conducted a cross-sectional analysis of a prospective multicentre study of SLE patients. We applied the LLDAS and assessed whether there was agreement with the clinical status according to the physician's opinion. Results A total of 508 patients [92% women; mean age 50.4 years (s. d. 3.7)] were recruited and 304 (62.7%) patients were in the LLDAS. According to physician assessment, 430 (86.1%) patients were classified as remission or low activity. Overall agreement between both evaluations was 71.4% (95% CI: 70.1, 70.5) with a Cohen's κ of 0.3 [interquartile range (IQR) 0.22–0.37]. Most cases (96.1%) in the LLDAS were classified as remission or low activity by the expert. Of the patients who did not fulfil the LLDAS, 126 (70.4%) were classified as having remission/low disease activity. The main reasons for these discrepancies were the presence of new manifestations compared with the previous visit and a SLEDAI 2K score >4, mainly based on serological activity. Conclusions Almost two-thirds of SLE patients were in the LLDAS. There was a fair correlation between the LLDAS and the physician's evaluation. This agreement improves for patients fulfilling the LLDAS criteria. The discordance between both at defining lupus low activity, the demonstrated association of the LLDAS with better outcomes and the fact that the LLDAS is more stringent than the physician's opinion imply that we should use the LLDAS as a treat-to-target goal. [ABSTRACT FROM AUTHOR]

Abstract: The ESS-Bilbao Accelerator Center site at Lejoa UPV/EHU campus will be provided with a proton accelerator up to 300-400 MeV. In the first construction phase, a beam extraction will be set at the end of the DTL, which will produce a 50 MeV proton beam with an average current of 2.25 mA and 1.5 ms pulses at a frequency of 20 Hz. These beam characteristics allow to configure a low intensity neutron source based on Be (p, n) reactions, which enables experimentation with cold neutrons similar to that of LENS. The total beam power will be 112 kW, so the configuration of the neutron production target will be based on a rotating disk of beryllium slabs facing the beam on one side and a cryogenic methane moderator on the other, with the target-moderator system surrounded by a beryllium reflector. In this paper, first estimates will be presented for thermomechanical conditions of the target cooling scheme, neutron source intensities, and cold neutron pulses. [Copyright &y& Elsevier]

Six out of ten users of Internet in Spain - 61.7% - are registered in the social network Facebook and two out of ten - 20.8% - in Tuenti, so these two networks lead the ranking of the social networks that have the greater number of users in that country. In the same way, eight out of ten Spanish Internet users that are connected to some social network -79.3%- do it with the aim of maintaining relationships of friendship or enlivening the contact with their friends. Consequently, it justifies the success of networks of leisure. The results of an exploration research developed between January 2009 and January 2010 have confirmed that both networks share many of their communicative possibilities: creating events and inviting friends; publishing photos, videos, events or links; notifying the assistance to some event; shaping photograph albums; sharing what somebody carries out at real-time with the rest of friends; a chat; telling of the birthday and so on. Tuenti led the market of the social networks in Spain from its creation in 2006 until December 2008, when Facebook exceeded it. Which causes it? What caused that many of the users of Tuenti preferred Facebook nowadays? The results of a survey to 100 users of both social networks point out the identification of Tuenti with excessively young public's profiles and its alleged obsession for resembling Facebook. [ABSTRACT FROM AUTHOR]