1. Tumoral volume measured preoperatively by magnetic resonance imaging is related to survival in endometrial cancer.
- Author
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Coronado, Pluvio J., Santiago-López, Javier de, Santiago-García, Javier de, Méndez, Ramiro, Fasero, Maria, and Herraiz, Miguel A.
- Subjects
AGE distribution ,CANCER patients ,CANCER relapse ,CONFIDENCE intervals ,MAGNETIC resonance imaging ,MEDICAL records ,MULTIVARIATE analysis ,PREOPERATIVE care ,SURVIVAL ,WOMEN'S health ,ENDOMETRIAL tumors ,RECEIVER operating characteristic curves ,ACQUISITION of data methodology - Abstract
Background: The aim of the study was to determine if the endometrial tumor volume (TV) measured by magnetic resonance imaging (MRI-TV) is associated with survival in endometrial cancer and lymph nodes metastases (LN+). Patients and methods: We evaluated the MRI imaging and records of 341 women with endometrial cancer and preoperative MRI from 2008 to 2018. The MRI-TV was calculated using the ellipsoid formula measuring three perpendicular tumor diameters. Tumor myometrial invasion was also analyzed. Results: Higher MRI-TV was associated with age ≥ 65y, non-endometrioid tumors, grade-3, deep-myometrial invasion, LN+ and advanced FIGO stage. There were 37 patients with LN+ (8.8%). Non-endometrioid tumors, deep-myometrial invasion, grade-3 and MRI-TV ≥ 10 cm
3 were the factors associated with LN+. Using a receiver operating characteristic [ROC] curve, the MRI-TV cut-off for survival was 10 cm3 (area under curve [AUC] = 0.70; 95% CI: 0.61–0.73). 5 years disease-free (DFS) and overall survival (OS) was significantly lower in MRI-TV ≥ 10 cm3 (69.3% vs. 84.5%, and 75.4% vs. 96.1%, respectively). MRI-TV was considered an independent factor of DFS (HR: 2.20, 95% CI: 1.09–4.45, p = 0.029) and OS (HR: 3.88, 95% CI: 1.34–11.24, p = 0.012) in multivariate analysis. Conclusions: MRI-TV was associated with LN+, and MRI-TV ≥ 10 cm3 was an independent prognostic factor of lower DFS and OS. The MRI-TV can be auxiliary information to plan the surgery strategy and predict the adjuvant treatment in women with endometrial cancer. [ABSTRACT FROM AUTHOR]- Published
- 2021
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