1. Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000-2015.
- Author
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Pérez-Nadales, Elena, Alastruey-Izquierdo, Ana, Linares-Sicilia, María José, Soto-Debrán, Juan Carlos, Abdala, Edson, García-Rodríguez, Julio, Montejo, Miguel, Muñoz, Patricia, Salavert Lletí, Miguel, Rezusta, Antonio, Pérez de Pipaón, Maite Ruiz, Yáñez, Lucrecia, Merino, Esperanza, Campos-Herrero, María Isolina, Costa-Mateo, José María, Fortún, Jesús, García-Lozano, Tomás, Garcia-Vidal, Carolina, Fernández-Ruiz, Mario, and Sánchez-Reus, Ferrán
- Subjects
ANTIFUNGAL agents ,FUNGI ,NEUTROPENIA ,MYCOSES - Abstract
Invasive fusariosis (IF) is associated with severe neutropenia in patients with concurrent hematologic conditions. We conducted a retrospective observational study to characterize the epidemiology of IF in 18 Spanish hospitals during 2000-2015. In that time, the frequency of IF in nonneutropenic patients increased from 0.08 cases per 100,000 admissions in 2000-2009 to 0.22 cases per 100,000 admissions in 2010-2015. Nonneutropenic IF patients often had nonhematologic conditions, such as chronic cardiac or lung disease, rheumatoid arthritis, history of solid organ transplantation, or localized fusariosis. The 90-day death rate among nonneutropenic patients (28.6%) and patients with resolved neutropenia (38.1%) was similar. However, the death rate among patients with persistent neutropenia (91.3%) was significantly higher. We used a multivariate Cox regression analysis to characterize risk factors for death: persistent neutropenia was the only risk factor for death, regardless of antifungal therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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