1. Co-Occurrence of mcr-1 and qnrS1 on an IncHI2 Plasmid in Clinical Isolates of Salmonella Typhimurium in Spain.
- Author
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Trujillo-Soto T, Machuca J, Arca-Suárez J, Rodríguez-Iglesias M, and Galán-Sánchez F
- Subjects
- Bacterial Proteins, Drug Resistance, Multiple, Bacterial, Gene Expression Regulation, Bacterial, Humans, RNA, Bacterial, RNA, Long Noncoding, Salmonella Infections epidemiology, Salmonella typhimurium drug effects, Salmonella typhimurium genetics, Spain epidemiology, Plasmids genetics, Salmonella Infections microbiology, Salmonella typhimurium metabolism
- Abstract
Salmonella enterica is a well-adapted zoonotic bacterium associated to cases of gastroenteritis and bacteremia with increased morbidity and mortality. In this study, three isolates of Salmonella Typhimurium obtained from human clinical samples, showing colistin resistance and low-level resistance to quinolones, have been genetically characterized. We detected the co-occurrence of mcr-1 and qnrS1 on a single IncHI2 plasmid in isolates of Salmonella Typhimurium obtained from Spanish children without a travel history. The multiresistant region contained numerous resistance genes. Isolates were clonally related, which suggests the presence of these clones in the community and the potential to cause outbreaks affecting the most susceptible population. It is necessary to monitor the presence of these plasmid-mediated resistance genes in human European strains of Salmonella spp. because of the risk of producing outbreaks of community-acquired infections.
- Published
- 2019
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