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1. A randomized, multicenter, open-label clinical trial to assess the anamnestic immune response 4 to 8 years after a primary hepatitis B vaccination series.

Author

Diez-Domingo J, Flores SA, Martin JC, Klopfer SO, Schödel FP, and Bhuyan PK

Subjects
Child, Child, Preschool, Female, Hepatitis B Vaccines adverse effects, Humans, Male, Spain, Time Factors, Hepatitis B prevention & control, Hepatitis B Antibodies blood, Hepatitis B Vaccines administration & dosage, Hepatitis B Vaccines immunology, Immunization, Secondary
Abstract

This open-label, randomized study challenged 4- to 8-year-old children from Spain (N = 1478) with a single dose of hepatitis B vaccine to estimate anamnestic responses. At the time of preimmunization, 15.9% to 51.2% of subjects had antibody values ≥10 mIU/mL. One month postimmunization, 91.6% to 97.3% of subjects had antibody titers ≥10 mIU/mL. There were no serious, vaccine-related, adverse experiences, and no discontinuations as a result of adverse experience.

Published
2010
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