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Many current investigations have analysed adolescents' risky ICT behaviours (such as excessive or addictive use), but few have explored the characteristics of low-risk behaviour in this regard. This study aimed to explore the psychosocial profile of a sample of 593 Spanish adolescents aged 13 to 18 who have been categorized as low-risk ICT users. To this end, the low-risk ICT use group was calculated using the "multitasking while doing homework index" and a set of items on risky ICT behaviour. Chi-squared and t-tests were performed and a forward stepwise binary logistic regression was carried out to determine the explanatory variables for low-risk ICT use. The results showed that some 7.1% were classified as low-risk ICT users, with a higher percentage of girls. These users' profile was characterised by: lower digital self-efficacy with social networking applications; less generalized ICT use and a less dependent attitude; less extroversion and more agreeableness and conscientiousness; higher academic self-concept; having rules for ICT use at home; and less insecure and anxious attachment to parental figures. The variables that predicted the likelihood of low-risk ICT behaviour were: high academic self-concept; low perceived separation anxiety from loved ones; and high agreeableness scores. These results are useful for proposing psycho-socio-educational interventions to promote healthy ICT use.

The participation of citizens in democratic societies depends on their ability to understand scientific knowledge and apply it to everyday life situations. Thus, promoting scientific literacy from an early age should be among the main priorities in democratic societies. Dialogic Scientific Gatherings (DSGs) have successfully promoted scientific literacy among adults. This research intends to take a step forward in studying DSG implementation's transferability in promoting scientific literacy in primary school children from a culturally diverse school placed in a low socioeconomic neighborhood in Spain. Drawing upon Communicative Methodology, this case study has collected data through semi-structured interviews and communicative observations. The results show that: (1) DSG enhance scientific literacy, specifically instrumental learning, analytical and critical thinking and social abilities; and (2) the promotion of scientific literacy has an impact on decision-making and participation in society. Furthermore, although this research is a case study implemented in one school, it shows that DSG can be transferred to a culturally diverse school.

The main aim of this study was to assess the criterion validity of the Sedentary Behavior Questionnaire (SBQ) to measure SB in community-dwelling older adults using thigh-measured accelerometry as the criterion method. 801 participants (75.6 ± 6.1 years old, 57.6% females) provided valid thigh-based accelerometer data (activPAL/Axivity) and completed the SBQ. Criterion validity was assessed using Spearman's Rho coefficients. Bland--Altman plots, including 95% limits of agreement and Intraclass Correlation Coefficient (ICC), were used to assess the agreement between self-report and device-measured daily SB time. Strength of the association was examined using multiple linear regression. There was a weak correlation (Rho = 0.25, p < 0.001) between self-reported and device-based SB measures. The SBQ under-estimated daily SB time compared to accelerometry. Our results highlighted an overall weak-to-moderate correlation between measures, with significant differences between each country's version. Researchers should be cautious when using the SBQ to provide an estimation of SB time in older adults.

Examples of applications of equilibrium-based methods for multicomponent separations usually require the use of simulation packages, which do not allow students to follow the involved algorithms step by step. Excel spreadsheets with examples of six such rigorous methods have been used with MSc students of Chemical Engineering of the University of Alicante (Spain), showing a significant enhancement of their ability to apply these methods.

This paper addresses the phenomenon of the pedagogical renewal taking place in Spain, which started around the turn of this century, from a socio-historical perspective and within the broader context of neoliberalism. It traces the evolution of these transformative educational pathways through the course of the twentieth century, focusing particularly on events that took place during the periods 1920-1937 and 1960-1985 as the key predecessors to the current reform drive, and it discusses the upsurge of new technologies and their impact in the area of pedagogical renewal. The conclusions drawn are the outcome of exhaustive bibliographical review, extensive interviews with key figures in the historical and current renewal processes, and the theoretical discussions that took place among the team of researchers at the University of Girona who developed the research work entitled "The third wave of pedagogical renewal in Catalonia" as part of the ARMIF 2016-2019 programme. The conclusion is that education needs to be politicised to the effect that school is understood as a space where pupils learn how to live as a community through the recognition of and for others and allowing the school community to be affected by what surrounds its pupils. Particular attention is drawn to the use of technological devices for their potential to control, and a call is made to the educational community to address the root reason for education, in other words its purpose, to bring about truly emancipatory change rather than simply introducing adaptive innovations.

This paper presents the experience of an initiative, the EXPLORE courses, designed to bring science and technology closer to secondary school. The EXPLORE courses, organised by "EXPLORATORI: Natural Resources" project, are particularly addressed to secondary school teachers and are conducted at Catalonia (North East of Spain). The main objective is to provide secondary school teachers with the opportunity to explore the natural resources. Based on a combination of face-to-face and online learning, the programme of the courses uses an interdisciplinary approach, integrating Science, Technology, Engineering, and Mathematics (STEM) and STEAM (STEM + art) fields. Data presented in this paper correspond to the 2012 and 2013 editions. The results, which were obtained from a written questionnaire completed by teacher participants of EXPLORE courses, indicate that more than 70% of secondary school teachers were encouraged to introduce some course contents on their teaching classes after participating in an EXPLORE course.

The present study focused on instruction in identifying the 1st sounds of different words. We taught this phonological awareness skill in a mainstream classroom through an evidence-based strategy of time delay to a student with severe intellectual and developmental disability. We implemented the time-delay strategy within a single-subject design and a multiple baseline across 3 different sets. Results indicated that the student learned to identify the initial letter sound of the words taught once the intervention ended and across the maintenance period. Contributions and limitations of the study are presented, and future research and practical implications are discussed.

Data from 949 children and adolescents with intellectual disability ages 5 to 16 for whom the Supports Intensity Scale-Children's Version-Catalan Translation was completed was used, in combination with data from the U.S. standardization sample, to examine measurement invariance and latent differences in the Catalonian sample. Results suggest that the same set of items can be used to measure support needs across U.S. and Catalonia samples and that there are age-related differences in support needs in the Catalonia sample, particularly between children ages 5 to 10 and 11 to 16 years of age. This differs from findings with the U.S. sample, where differences were found in a greater number of age cohorts. Implications for future research and practice are discussed.

People with intellectual disabilities (ID) often engage in problem behaviors, such as verbal or physical aggression, property destruction, or self-injury. These behaviors become a challenge for the families and for professionals. Functional behavioral assessment (FBA) is a method used to identify variables that influence or maintain challenging behaviors (CB) and aid in the development of intervention plans. Two major concerns of FBA are that it is time-consuming and requires specialized professionals to interpret data from the natural or experimental environment. Therefore, indirect FBA methods can be used as an alternative. An instrument with excellent psychometric properties that aims to identify the function of behavior is the Questions About Behavioral Function (QABF). This study presents the adaptation of the QABF in Spain. Data from 300 participants with ID and 328 behavioral problems were obtained. An exploratory factor analysis was conducted to identify the components of the QABF, and the test-retest reliability was assessed to evaluate the stability of the QABF over time. (Contains 3 tables.)

WIRIS quizzes are an online mathematics tool for educational purposes that upgrade Moodle quizzes and allow the development of personalized quizzes using random data and conditional instructions. WIRIS quizzes can be used in any mathematics or science degree; their complex operators allow it to be used to solve electrical circuits. This tool promotes autonomous student learning and enables teachers to monitor that learning and make adjustments if necessary. Therefore, this tool improves teaching quality. It can also be used as an assessment tool by both the teacher and the student. This paper shows how WIRIS quizzes have been integrated into the virtual campus of the Polytechnic University of Catalonia (UPC), Spain, to teach electrical circuits. Lessons learned in performing and using WIRIS quizzes with second-year students at the UPC are shown. (Contains 9 figures and 1 table.)

Adolescent pedestrians are a particularly vulnerable group of road users. This research tested the applicability of the recently developed Adolescent Road user Behaviour Questionnaire (ARBQ) amongst a sample of 2006 Spanish adolescents. Confirmatory Factor Analysis of the full scale found that the original three factors did not adequately fit the data, but an acceptable fit was obtained for the shortened 21-item version of the scale. In line with research from the UK, the present study found that males reported more unsafe road crossing behaviour and playing on the roads, but there was no gender difference for engaging in planned protective behaviour. This research also confirmed that unsafe road crossing behaviour increased with age, while dangerous playing on the road and planned protective behaviours both decreased with age. The present study also confirmed that the ARBQ is a useful tool for investigating the safety-related behaviour of adolescents on the road.

This paper describes a model for the analysis of the quality of teaching and learning in higher education. Empirically validated through an extensive student-focused survey, this model puts forward a concept of quality that challenges that which is commonly used in institutional analysis. Research indicates that quality, rather than being a simple technical outcome, is a construction responding to the principle of situated action, in which different well-aligned functions exist within certain settings and contexts. The ELQ/AQA08 model proves a valuable evaluation tool for the analysis of teaching and learning practices and offers strong possibilities for the consolidation and improvement of key aspects of these experiences in the context of higher education. (Contains 1 figure and 2 tables.)

This study examines the sensitivity of future long-term care demand and expenditure estimates to official demographic projections in four selected European countries: Germany, Spain, Italy and the United Kingdom. It uses standardised methodology in the form of a macro-simulation exercise and finds evidence for significant differences in assumptions about demographic change and its effect on the demand for long-term care, and on relative and absolute long-term care expenditure. It concludes that mortality-rate assumptions can have a considerable influence on welfare policy planning. Relative dispersion between country-specific and Eurostat official estimates was found to be higher for the United Kingdom and Germany than for Italy and Spain, suggesting that demographic projections had a greater influence in those countries.

After examining several conceptual elements of peer-assisted learning and peer tutoring, this article presents a study analysing the effects of peer tutoring--with fixed and reciprocal roles--in the improvement of curricular competence of Catalan language skills, self-concept as a writer and satisfaction with pedagogical assistance. The results, using curricular competence improvement as a control, show an increase in self-concept as a writer for all students who were given the opportunity to act as tutors; either in fixed or in reciprocal role tutoring. Only fixed tutees, but not reciprocal tutees, feel more satisfied with their peer tutors than with the teacher's help. (Contains 4 tables.)

BACKGROUND: The objective of the current study was to determine whether overnight pulse oximetry in patients with amyotrophic lateral sclerosis is prognostic of the onset of awake respiratory failure and hospital admissions. METHODS: This was an observational study in a cohort of subjects with amyotrophic lateral sclerosis. The study included subjects with a baseline SpO2 ≥ 94% on home overnight pulse oximetry testing. Patients age ≥ 80 y and those with comorbidities and with poor short-term prognosis or sleep apnea were excluded. The subjects were classified as nocturnal desaturators according to percentage of sleep time with SpO2 < 90% (T90) > 10%. RESULTS: A total of 76 subjects were included: 40 men (53%), mean ± SD age 60 ± 14.4 y, mean ± SD body mass index 25.7 ± 4.60 kg/m2, and spinal presentation in 63.2%. After overnight pulse oximetry, 20 subjects (26%) were classified as desaturators and 56 (74%) as non-desaturators. In the first year, the subjects with nocturnal desaturation had respiratory failure more often compared with the subjects without desaturation (35% vs 10.91%; P = .02) and had a higher risk of developing respiratory failure during the course of the study (hazard ratio 2.48; P = .030). The desaturator group also had a higher rate of ≥ 1 admission (40% vs 7.3%; P = .01) and a higher likelihood of respiratory-related hospitalization (hazard ratio 2.41; P = .02). Median survival was almost 1 year less if T90 > 10% was observed in the overnight pulse oximetry: 21 months versus 32 months survival if T90 was ≤ 10%. CONCLUSIONS: In subjects with amyotrophic lateral sclerosis, nocturnal desaturation conferred a higher risk of respiratory failure and poorer prognosis. Even in the absence of other clinical criteria, early pulse oximetry should be performed and the need for nocturnal ventilatory support assessed. [ABSTRACT FROM AUTHOR]

This paper addresses the phenomenon of the pedagogical renewal taking place in Spain, which started around the turn of this century, from a socio-historical perspective and within the broader context of neoliberalism. It traces the evolution of these transformative educational pathways through the course of the twentieth century, focusing particularly on events that took place during the periods 1920-1937 and 1960-1985 as the key predecessors to the current reform drive, and it discusses the upsurge of new technologies and their impact in the area of pedagogical renewal. The conclusions drawn are the outcome of exhaustive bibliographical review, extensive interviews with key figures in the historical and current renewal processes, and the theoretical discussions that took place among the team of researchers at the University of Girona who developed the research work entitled "The third wave of pedagogical renewal in Catalonia" as part of the ARMIF 2016-2019 programme. The conclusion is that education needs to be politicised to the effect that school is understood as a space where pupils learn how to live as a community through the recognition of and for others and allowing the school community to be affected by what surrounds its pupils. Particular attention is drawn to the use of technological devices for their potential to control, and a call is made to the educational community to address the root reason for education, in other words its purpose, to bring about truly emancipatory change rather than simply introducing adaptive innovations. [ABSTRACT FROM AUTHOR]

The aim of this study was to analyse the eventual changes in health-related quality of life ( HRQoL) and left ventricular function ( LVF) over a 1-year follow-up period in a cohort of patients with lower risk myelodysplastic syndromes ( MDS) receiving standard supportive treatment, in order to identify potential clues for early clinical intervention, as well as to analyse how they relate to haemoglobin levels and other aspects of the disease. A total of 39 adult anaemic patients with lower risk MDS were included in a prospective, observational, multi-centre study. Changes in performance status, functional capacity and HRQoL were collected by using standardised measures ( ECOG scale; SPPB, Short Physical Performance Battery; SF-36, Short-Form 36 questionnaire; QLQ-C30, Quality of Life Core Questionnaire; FACT-An, Functional Assessment of Cancer Therapy-Anaemia scale questionnaires respectively). Need for transfusion (Linear Analogue Scale Assessment), as perceived independently by the patient and the haematologist, was also recorded. No changes in HRQoL (or LVF) were found, except for slight reductions in SF-36 physical function ( P = 0.034), SPPB gait speed ( P = 0.038) and FACT-An score ( P = 0.029), all without apparent immediate clinical relevance for HRQoL, that were unrelated to changes in haemoglobin level. Periodical evaluation of gait speed may assist the clinician in early detection of patient's occult functional decline before it becomes clinically relevant. [ABSTRACT FROM AUTHOR]

Aim: Describe the incidence of non-traumatic amputation in a Spain region and identify the risk factors associated with the level of amputation and reamputation.Methods: Retrospective study on non-traumatic lower-extremity amputees in a Spanish region between 2007 and 2013. A descriptive, bivariate and multivariate analysis was performed using bivariate logistic regression. Statistical significance p≤0.05, SPSS V.21.Results: 495 amputations were carried out in 353 patients. 81.0% (n=286) were men, mean age 68.7±10.8 years. The most frequent levels of amputation were digital (45.9%) and above-knee (40.5%). About 30% of the patients were reamputated. The multivariate analysis revealed that the factors independently related to the need for a minor lower-extremity amputation were DM [OR 3.79 (CI 95% 2.0-7.27)], foot ulcer [OR 5.82 (CI 95% 2.24-15.11)] and previous ipsilateral amputation [OR 3.19 (CI 95% 1.21-8.42)]. The risk factors independently related to the need for reamputation were DM [OR 2.21 (CI95% 1.09-4.49)], smoking [OR 2.45 (CI95% 1.33-4.50)] and previous revascularization [OR 2.75 (CI95% 1.57-4.83)].Conclusions: Determining the incidence of amputations in diabetic patients as an indicator of quality makes it possible for health services to be evaluated. In patients with DM the most common reamputations are minor and ipsilateral. [ABSTRACT FROM AUTHOR]

This article retrospectively analyses the spatial distribution and dog- and environmental-level risk factors associated to Leishmania infantum seroprevalence among 807 asymptomatic dogs in the Municipality of Crevillente in Alicante in southeast Spain in 1999. They represented 60% of the dogs in this 103 km2 area, with a human census of 27 034 people and 90% lived in Crevillente town. The estimated seroprevalence (95% confidence interval) in 714 dogs ≥1-year old was 22% (19–25) however; it was 12% (8–15) in town dogs and 0–100% in other administrative zones. High–medium seroprevalence zone clustered along a northeast–southwest fringe and around the town. They comprised the highest and driest inhabited part of the municipality, where farmland was interspersed by residential detached houses, whilst null–low seroprevalence zones included larger farmland extensions and two small rural villages. Predominant vegetation and ground soil type were bush, non-irrigated fruit trees and conglomerate crust and sandstone in medium–high seroprevalence zones and irrigated grassland and fruit trees and colluvial deposits in null–low seroprevalence zones. Random effects logistic regression indicated that the prevalence of infection with L. infantum was higher for dogs sharing residence with infected dogs, increased until 5–6 years old and with body weight and was associated to increasing conglomerate crust and low surface water in the dog’s zone of residence. The study confirms that L. infantum infection is endemic in this part of Spain and shows that prevalence can vary significantly within a small area depending on specific demographic and environmental factors conditioning the habitat of the local L. infantum vector, Phlebotomus perniciosus. It suggests similar low-scale variability is present in other geographically variable endemic areas and should be investigated to design Leishmaniosis risk maps and cost-effective, evidence-based, targeted control interventions. [ABSTRACT FROM AUTHOR]

This paper investigates the effects of varying attribute ranges to find evidence of anomalous preference formation or, by contrast, of apparent differences in preferences linked to unexplained error variance. A choice experiment study aimed at estimating tourists' preferences for alternative climate change adaptation policies in Mallorca, Spain, has provided the empirical framework varying the ranges of values for all non-cost attributes between two split-sample treatments. Our results suggest that the greater difficulty associated to wider ranges increases the variance with which respondents make their choices which are, in this case, more random. However, once scale differences between treatments are controlled for, the varying attribute range has no effect on utility parameters (preferences) and marginal willingness to pay. • Attribute range effects disappear once scale differences are controlled for. • Trade-offs between alternatives become harder to make with wider attribute ranges. • Wider attribute ranges increases the variance with which respondents make choices. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Fomento Social is the property of ETEA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract: We examine the influence of socio-environmental (and birth cohort specific) effects on both adult height and gender dimorphism (height gap). Our data set is from contemporary Spain, a country governed by an authoritarian regime for about 40 years. Both OLS and quantile regression approaches are used to examine these patterns. Furthermore, we then draw upon a Blinder-Oaxaca decomposition approach to explain the influence of socio-political environment in explaining gender dimorphism. Our findings point to a significant increase in adult height in the generations that benefited from the country''s economic liberalization in the 1950s, and especially among those brought up after the transition to democracy in the 1970s. In contrast, individual heterogeneity suggests that only in recent generations has “height increased more among the tallest”. We also find that the effects of education on height are greater among shorter individuals. Although the mean gender difference in height is 11.7cm, birth cohort and capabilities effects along with other controls explain on average roughly 4% of the gender height dimorphism, irrespective of the quantile considered. [Copyright &y& Elsevier]

Traveltime seismic tomography used to aid subway tunnel drilling in Barcelona, Spain, provides a detailed characterization of the shallow subsurface, including a complex network of faults and dikes. We encountered many difficulties while working in this urban setting, such as cultural noise and the inability to deploy instruments along much of the tunnel trace because of the street layout. Furthermore, the shallow subsurface is highly heterogeneous (because of gas and water lines, building foundations, and the sewage system), obscuring deeper structures. We acquired seismic data using a 10-s vibroseis sweep that provided relatively good signal-to-noise (S/N) ratio. First-arrival traveltime tomography proved to be a key tool to differentiate rock volumes characterized by different physical properties-- in particular, the contact between the weathered upper layer and the more competent rock below. We interpreted the seismic results using surface geologic observations and borehole cores. Low seismic velocities (600--1200 m/s) characterize the shallow part of the subsurface, representing quaternary sediments and weathered granite. Several high-velocity anomalies (up to 5500 m/s) are interpreted as porphyritic dikes and are surrounded by low-velocity anomalies that correspond with fault systems that cut and displace the dikes. The tomographic velocity models also provide a detailed image of an important Miocene fault that intersects the tunnel trace. These results provide insights important for the drilling process. [ABSTRACT FROM AUTHOR]

Copyright of Policy & Politics is the property of Policy Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract: Tourism statistics point towards increased tourist mobility in holiday destinations, with a subsequent rise in associated externalities, above all those related with the use of hire cars. This paper therefore suggests that a fixed-rate tax should be levied on vehicle hire in order to reduce congestion externalities and thus achieve more efficient traffic levels. With this purpose in mind, count data models were used to assess alternative ways of modelling the demand function for hire cars in Mallorca (Spain) so that the corrective potential of the proposed tax could then be analysed. Although the inelasticity that was observed might indicate a low short-run capacity to internalise costs, it also represents a high potential for raising revenue that could be used to fund alternative means of group transport. In the mid-run, this would lead to increased elasticity and, in consequence, to better internalising effectiveness. [Copyright &y& Elsevier]

Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Analyzes the evolution of Spanish municipalities and describes the service quality improvement programs applied to municipal services and to the whole set of services provided in a city. Quality improvement in municipal service; Barriers to service quality measurement; Developments of service quality measurement in Spanish local government; Recommendations.

Abstract: An epidemiological study was carried out to investigate asymptomatic Leishmania infantum infection by PCR and ELISA in wild rabbits, humans and domestic dogs in southeastern Spain. Seroprevalence was 0% (0/36) in rabbits, 2% (13/657) in humans and 7% (14/208) in dogs. The prevalence of PCR-positives was 0.6% (1/162) in rabbits tested in a wide range of tissue samples, 2% (8/392) in humans analysed in blood samples and 10% (20/193) and 67% (29/43) in dogs analysed in blood and lymphoid tissue samples, respectively. Results suggest that wild rabbits have a very low risk of becoming chronically infected with L. infantum, and provide further evidence that cryptic L. infantum infection is widespread in the domestic dog population and is also present in a comparatively smaller proportion of healthy humans. The epidemiological and clinical implications of these findings are discussed. [Copyright &y& Elsevier]

Objectives: To study whether disease status at treatment initiation has changed after the issue of the ASAS classification criteria., Methods: REGISPONSERBIO registers patients with axial spondyloarthritis (axSpA) on biological treatment since 2013. It includes patients starting biological treatment (incident) or already on biological therapies (prevalent). Patients in both groups were compared in terms of: age at disease onset and at treatment start, disease duration, gender, HLA-B27, body mass index (BMI), BASDAI, BASFI, C-reactive protein, ESR, metrological data, ASQoL, WAPAI, extra-articular manifestations, comorbidities, radiological study, type of biological treatment and concomitant treatments., Results: 256 patients were included, of whom 174 (65%) were already on biologic therapy. Compared to incident patients, prevalent patients started treatment with longer disease duration (15 vs. 8.6 years; p<0.001), a higher proportion of them were men (83% vs. 67%; p=0.01), a smaller proportion of them showed non-radiographic axial spondylarthritis (nr-axSpA)(17% vs. 32%; p<0.01), and a higher proportion had HLAB27 (85% vs. 73%; p=0.02). There were no statistically significant differences in terms of disease activity, degree of disability, quality of life, or prevalence of extra-articular manifestations., Conclusions: Data suggest that, after the issue of the new classification criteria for SpA, biological therapy is being administered earlier than previously in SpA patients and in a higher proportion of patients with nr-axSpA. However, this change in prescribing profile, apparently, has not caused an over-treatment, as patients do not seem to have a lower disease burden than prior to the issue of the criteria.

Objective: To assess HLA-B27 influence on the clinical phenotype of Ankylosing Spondylitis (AS) patients., Method: An observational, cross-sectional and descriptive study of AS patients from the Spanish REGISPONSER database was performed. Demographic, clinical, disease activity (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP)), and radiographic data (Bath Ankylosing Spondylitis Radiology Index (BASRI) score) were compared regarding HLA-B27 status. A univariate and multivariate analysis was performed to identify variables independently related to the presence of HLA-B27., Results: Data from 1235 patients (74.8% male) were analyzed; 1029 were HLA-B27 positive (83%). HLA-B27-positive patients showed higher family aggregation and an earlier onset of disease compared with those who were HLA-B27 negative. HLA-B27-negative patients presented statistically higher BASDAI and BASFI scores and higher prevalence of arthritis, dactylitis, and extra-articular manifestations (psoriasis and inflammatory bowel disease (IBD)) but not anytime uveitis compared with those who were HLA-B27 positive. In the multivariate analysis, family history (odds ratio (OR) 2.10, 95% confidence interval (CI) 1.27-3.49), younger age at diagnosis (OR 0.97, 95% CI 0.96-0.98), presence of peripheral arthritis (OR 0.53, 95% CI 0.32-0.89), dactylitis (OR 0.16, 95% CI 0.05-0.56), psoriasis (OR 0.45, 95% CI 0.26-0.78), and IBD (OR 0.22, 95% CI 0.12-0.40) were the main variables independently related to the presence or not of HLA-B27., Conclusion: In Caucasian AS patients, the presence of HLA-B27 is related to an earlier disease onset and higher family aggregation. Absence of HLA-B27 is related to a higher frequency of peripheral arthritis, dactylitis, and extra-articular manifestations. Being HLAB27 positive is not related to a higher burden of disease or anytime uveitis.

Morphology is the basis of the diagnosis of myelodysplastic syndromes (MDS). The WHO classification offers prognostic information and helps with the treatment decisions. However, morphological changes are subject to potential inter-observer variance. The aim of our study was to explore the reliability of the 2008 WHO classification of MDS, reviewing 100 samples previously diagnosed with MDS using the 2001 WHO criteria. Specimens were collected from 10 hospitals and were evaluated by 10 morphologists, working in five pairs. Each observer evaluated 20 samples, and each sample was analyzed independently by two morphologists. The second observer was blinded to the clinical and laboratory data, except for the peripheral blood (PB) counts. Nineteen cases were considered as unclassified MDS (MDS-U) by the 2001 WHO classification, but only three remained as MDS-U by the 2008 WHO proposal. Discordance was observed in 26 of the 95 samples considered suitable (27 %). Although there were a high number of observers taking part, the rate of discordance was quite similar among the five pairs. The inter-observer concordance was very good regarding refractory anemia with excess blasts type 1 (RAEB-1) (10 of 12 cases, 84 %), RAEB-2 (nine of 10 cases, 90 %), and also good regarding refractory cytopenia with multilineage dysplasia (37 of 50 cases, 74 %). However, the categories with unilineage dysplasia were not reproducible in most of the cases. The rate of concordance with refractory cytopenia with unilineage dysplasia was 40 % (two of five cases) and 25 % with RA with ring sideroblasts (two of eight). Our results show that the 2008 WHO classification gives a more accurate stratification of MDS but also illustrates the difficulty in diagnosing MDS with unilineage dysplasia.

Objective: To compare the clinical, demographic, and serologic characteristics and the treatment of patients diagnosed with ankylosing spondylitis (AS) from Europe (EU) and Latin America (LA)., Methods: We included 3439 patients from national registries: the Spanish Registry of Spondyloarthritis (REGISPONSER), the Belgian registry (ASPECT), and the Latin American Registry of Spondyloarthropathies (RESPONDIA). We selected patients with diagnosis of AS who met the modified New York classification criteria. Demographic, clinical, disease activity, functional, and metrological measurement data were recorded. Current treatment was recorded. The population was classified into 2 groups: patients with disease duration < 10 years and those with disease duration ≥ 10 years. A descriptive and comparative analysis of variables of both groups was carried out., Results: There were 2356 patients in EU group and 1083 in LA group. Prevalence of HLA-B27 was 71% in LA group and 83% in EU group (p < 0.001). We found a greater frequency of peripheral arthritis and enthesitis (p < 0.001) in the LA population; prevalence of arthritis was 57% in LA and 42% in EU, and for enthesitis, 54% and 38%. Except for treatment with anti-tumor necrosis factor (anti-TNF), the use of nonsteroidal antiinflammatory drugs (NSAID), corticosteroids, and disease-modifying antirheumatic drugs (DMARD), and the association of anti-TNF and methotrexate use showed a significant difference (p < 0.001) in the 2 populations., Conclusion: The principal differences in the clinical manifestations of patients with AS from EU and LA were the greater frequency of peripheral arthritis and enthesitis in LA group, the higher percentage of HLA-B27 in EU group, and the form of treatment, with a greater use of NSAID, steroids, and DMARD in the LA group.

Objectives: To analyse potential differences in disease phenotype between patients with familial ankylosing spondylitis (AS) and sporadic AS., Methods: A cross-sectional study was conducted on all patients with definite AS registered at the internet database REGISPONSER. Sociodemographic data, clinical features, spinal mobility measurements, the Bath AS disease activity index (BASDAI), functional index (BASFI) and radiology index (BASRI), laboratory data (ESR, CRP, HLA-B27), overall patient assessment of the disease (VAS), and treatments used were obtained. Familial AS was considered when the patient was confirmed to have first-degree relatives with spondyloarthropathy. The Chi-square test and Mann-Whitney U-test were used for the statistical analysis., Results: A total of 1316 AS patients (990 males, 326 females; mean age 48.2 ± 12.6 years), with mean age at symptom onset 26.1 ± 8.5 years, were evaluated. The prevalence of familial AS was 20% (n=263). Familial and sporadic AS groups presented differences (p<0.05) in the following parameters: female (34.6% vs. 22%), mean age at symptom onset (25.0±9.2 years vs. 27.3 ± 10.0 years), disease duration (23 ± 13 years vs. 21 ± 12 years), uveitis (27.5% vs. 19.3%), presence of HLA-B27+ (93% vs. 83%), VAS for overall patient assessment (5.0 cm vs. 4.4 cm), BASDAI (4.4 cm vs. 4.0 cm) and response to NSAID (82% vs. 74%)., Conclusions: Patients with familial AS were younger at symptom onset and had poorer VAS for overall patient assessment and BASDAI than the other group. There was a higher prevalence of females, uveitis, positive HLA-B27, hip prostheses and a better response to NSAID in the familial AS group.

Objective: To present the usefulness of a centralized system of data collection for the development of an international multicentre registry of SpA., Method: The originality of this registry consists in the creation of a virtual network of researchers in a computerized Internet database. From its conception, the registry was meant to be a dynamic acquiring system., Results: REGISPONSER has two developing phases (Conception and Universalization) and gathers several evolving secondary projects (REGISPONSER-EARLY, REGISPONSER-AS, ESPERANZA and RESPONDIA). Each sub-project answered the necessity of having more specific and complete data of the patients even from the onset of the disease so, in the end, obtaining a well-defined picture of SpAs spectrum in the Spanish population., Conclusion: REGISPONSER is the first dynamic SpA database composed of cohorts with a significant number of patients distributed by specific diagnosis, which provides basic specific information of the sub-cohorts useful for patients' evaluation in rheumatology ambulatory consulting.

Purpose: Joint lavage (JL), involves the passage of cold sterile 0.9% saline through the knee joint in order to have the fluid reach the inside of the joint capsule. This technique was evaluated as a local treatment for osteoarthritis (OA) of the knee alone (JL) and in combination with intra-articular infiltration with glucocorticoids (JLC)., Patients and Methods: An overall 299 knees belonging to 205 patients (22% males, 78% females) with a mean age of 67 +/- 8 years and osteoarthritis of the knee of radiological grade II or III on the Kellgren scale were randomised in the ratio of 1:4 into two therapeutic groups, namely: JL (n = 62) and JLC (n = 237). All patients received joint lavage on day 0; in those of the JLC group, joint lavage was followed by infiltration of 40 mg of triamcinolone acetonide. The efficacy of both treatments was assessed by recording the corresponding values for the following variables: pain strength as measured by a visual analogy scale (VAS), effusion, crepitation, restricted motion, of osteoarthritis of the knee. spontaneous pain, pain on pressure, pain on passive motion and pain on active motion; all of these were recorded at the onset of the study, and after 1 and 3 months., Results: There were no significant differences in the values of the variables at the different followup times. Also, pain severity was similar in both treatment groups. Thus, VAS for pain was 7.3 +/- 0.3 for the JL group and 7.1 +/- 0.2 for the JLC group at the onset, and decreased to 3.0 +/- 0.3 in the former and 2.8 +/- 0.2 in the latter after 1 month; the decrease was statistically significant in both cases. After 3 months, the JL and JLC groups had a VAS of 3.5 +/- 0.3 and 3.8 +/- 0.2, respectively., Conclusions: The results of this work suggest the absence of significant differences between the two treatments, such that both joint lavage alone and with infiltration with corticoids can be concluded as similarly effective for the symptomatic management