1. Incidence of depression in patients with hepatitis C treated with direct-acting antivirals.
- Author
-
Egmond E, Mariño Z, Navines R, Oriolo G, Pla A, Bartres C, Lens S, Forns X, and Martin-Santos R
- Subjects
- Adult, Aged, Female, Hepatitis C epidemiology, Humans, Incidence, Logistic Models, Male, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales, Ribavirin therapeutic use, Risk Factors, Spain epidemiology, Time Factors, Treatment Outcome, Antiviral Agents therapeutic use, Depressive Disorder epidemiology, Hepatitis C drug therapy, Hepatitis C psychology
- Abstract
Objective: Depression has been associated with hepatitis C, as well as with its treatment with proinflammatory cytokines (i.e., interferon). The new direct-acting antiviral agents (DAAs) have minimal adverse effects and high potency, with a direct inhibitory effect on non-structural viral proteins. We studied the incidence and associated factors of depression in a real-life prospective cohort of chronic hepatitis C patients treated with the new DAAs., Methods: The sample was recruited from a cohort of 91 patients with hepatitis C, of both sexes, with advanced level of fibrosis and no HIV coinfection, consecutively enrolled during a 6-month period for DAA treatment; those euthymic at baseline (n=54) were selected. All were evaluated through the depression module of the Patient Health Questionnaire (PHQ-9-DSM-IV), at three time points: baseline, 4 weeks, and end-of-treatment., Results: The cumulative incidence (95%CI) of major depression and any depressive disorder during DAA treatment was 13% (6.4-24.4) and 46.3% (33.7-59.4), respectively. No differences were observed between those patients with and without cirrhosis or ribavirin treatment (p > 0.05). Risk factors for incident major depression during DAA treatment included family depression (relative risk 9.1 [1.62-51.1]), substance use disorder (11.0 [1.7-73.5]), and baseline PHQ-9 score (2.1 [1.1-3.1])., Conclusions: The findings of this study highlight the importance of screening for new depression among patients receiving new DAAs, and identify potential associated risk factors.
- Published
- 2020
- Full Text
- View/download PDF