1. Relationship between leptin and all-cause and cardiovascular mortality in chronic hemodialysis patients.
- Author
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Díez JJ, Bossola M, Fernández-Reyes MJ, Di Stasio E, Tazza L, Luciani G, Codoceo R, Iglesias P, Rodríguez A, González E, and Selgas R
- Subjects
- Aged, Body Mass Index, Cardiovascular Diseases mortality, Cause of Death, Cohort Studies, Comorbidity, Female, Follow-Up Studies, Humans, Italy epidemiology, Kaplan-Meier Estimate, Kidney Failure, Chronic mortality, Kidney Failure, Chronic therapy, Male, Middle Aged, Obesity blood, Obesity epidemiology, Proportional Hazards Models, Prospective Studies, Risk Factors, Spain epidemiology, Statistics, Nonparametric, Cardiovascular Diseases blood, Kidney Failure, Chronic blood, Leptin blood, Mortality, Renal Dialysis statistics & numerical data
- Abstract
Background: We aimed to evaluate the relationship between serum leptin and the leptin/body mass index (BMI) ratio with prevalent cardiovascular disease (CVD), and their influence on all-cause and CVD-related mortality in patients on hemodialysis (HD)., Methods: 118 stable HD patients (50 women, median [interquartile range] age, 65.1 [54.7-72.2] years) were studied. All patients had baseline measurement of serum leptin concentrations. Relationships between leptin and all-cause and CVD mortality were studied by means of survival analysis and Cox regression analysis., Results: The leptin/BMI ratio was similar in patients with and without CVD at baseline (0.65 [0.29-2.23] vs. 0.68 [0.29-1.49] ng·m2/ml·kg, respectively, NS). Multiple logistic regression analysis showed that there was not an independent association between leptin/BMI ratio and prevalent CVD. During the follow-up time, 52 (44.1%) patients died. CVD was the cause of death in 27 out of 52 (51.9%) deceased patients. Survival analysis and Cox proportional multivariate regression analysis showed that there were no significant relationships between leptin levels or the leptin/BMI ratio and all-cause and CVD-related mortality., Conclusion: These results do not support that, in stable HD patients, serum leptin concentrations and the leptin/BMI ratio are related with prevalent CVD. Leptin/BMI ratio seems not to be a risk factor for mortality in these patients.
- Published
- 2011
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