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There has been no previous clinical-immunological study of pemphigus in Spain. The aim of this study was to perform a retrospective analysis of pemphigus patients who had been followed for a period of 18 years in our centre. We characterized the autoantibody response, compared diagnostic assays and correlated the immunobiological data with phenotype and prognosis. Clinical, epidemiological and immunopathological data were collected from 40 patients. Patients sera were characterized by indirect immunofluorescence and enzyme-linked immunosorbent assay (ELISA). Epidemiological and clinical findings were comparable to other series. Mortality during follow-up was 0% and 6% in pemphigus foliaceus and vulgaris, respectively. Importantly, higher indirect immunofluorescence titres and anti-desmoglein 3 ELISA values of samples from untreated patients correlated significantly with a potentially worse clinical course. Moreover, there was a positive correlation between indirect immunofluorescence titres and anti-desmoglein 3 ELISA levels in pemphigus vulgaris patients. Based on our findings, initial high anti-desmoglein 3 antibodies in pemphigus patients correlate with a more adverse prognosis, which raises the question as to whether a more aggressive initial therapy is indicated in patients with this immunological pattern.

Background: The aim of the present study was to compare the eating habits of two urban populations (Vilanova i la Geltrú and Gavá) of the province of Barcelona, Spain, and determine the relation with the diet recommended in diabetes since this diet does not differ from what is considered "equilibrated diet"., Methods: One thousand thirty-four individuals randomly selected from Primary Health Care Centers (PHCC) by a systematic sampling of all the outpatient consultations over one year to whom a questionnaire on semiquantitative frequencies were studied with the aim of determining their everyday diet. All those between 13 and 80 years of age, residing in the two municipalities studied and who attended the PHCC over the period of the study were included in the study., Results: On comparison of both populations a statistically higher consumption (p < 0.01) of milk products, fish, vegetables, fruits and oils was observed in Vilanova i la Geltrú than in Gavá. Both groups presented a lower intake than recommended of fish, vegetables, and fruits. In contrast a high intake of sugar, ice cream and sugared beverages and foods were observed in the two populations studied and in the younger are groups., Conclusions: The population of Vilanova i la Geltrú have dietary habits which are closer to those recommended in the diet of diabetics than the population of Gavá.