1. Pharmacological activities of some Argyranthemum species growing in the Canary Islands.
- Author
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Badisa RB, Couladis M, Tsortanidou V, Chaudhuri SK, Walker L, Pilarinou E, Santos-Guerra A, and Francisco-Ortega J
- Subjects
- Animals, Anti-Infective Agents administration & dosage, Anti-Infective Agents pharmacology, Anti-Infective Agents therapeutic use, Antimalarials administration & dosage, Antimalarials therapeutic use, Antineoplastic Agents, Phytogenic administration & dosage, Antineoplastic Agents, Phytogenic therapeutic use, Caco-2 Cells drug effects, Candida albicans drug effects, Cell Line, Tumor drug effects, Humans, Malaria, Falciparum drug therapy, Medicine, Traditional, Microbial Sensitivity Tests, Parasitic Sensitivity Tests, Plant Components, Aerial, Plant Extracts administration & dosage, Plant Extracts therapeutic use, Plasmodium falciparum drug effects, Spain, Staphylococcus aureus drug effects, Antimalarials pharmacology, Antineoplastic Agents, Phytogenic pharmacology, Artemia drug effects, Asteraceae, Phytotherapy, Plant Extracts pharmacology
- Abstract
Methanolic extracts of eight subspecies of genus Argyranthemum were evaluated against brine shrimps, human cancer cell lines, malarial parasites and microorganisms under in vitro conditions. In the shrimp assay, samples of A. adauctum ssp. adauctum, A. adauctum ssp. erythrocarpon and A. frutetescens ssp. succulentum were active with ED50 values in the range of around 300 to 360 microg/ml. In the Caco-2, HepG2 and MCF-7 cell lines, the samples A. adauctum ssp. jacobaeifolium and A. adauctum ssp. palmensis were active with LC50 values ranging between 80-90 microg/ml. The secondary assay results of antimalarial activity of samples, A. adauctum ssp. adauctum, A. adauctum ssp. dugourii, A. adauctum ssp. erythrocarpon and A. adauctum ssp. jacobaeifolium have IC50 values <50 microg/ml. The samples demonstrated broad specific antimicrobial activity against five different microorganisms., (Copyright (c) 2004 John Wiley & Sons, Ltd.)
- Published
- 2004
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