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3 results on '"Chanock, Stephen J"'

1. SNPs Meet CNVs in Genome-Wide Association Studies: HGV2007 Meeting Report.

Author

Estivill, Xavier, Cox, Nancy J., Chanock, Stephen J., Pui-Yan Kwok, Scherer, Stephen W., and Brookes, Anthony J.

Subjects
CONFERENCES & conventions, GENOMICS, HUMAN genome, GENETIC polymorphisms, BIOINFORMATICS, GENETIC disorders
Abstract

Information about several topics discussed at the Ninth Meeting on Human Genome Variation and Complex Genome Analysis held in Sitges, Spain in September 2007 is presented. The event featured several presentations and discussions that focus on single nucleotide polymorphisms (SNPs). Topics also include the success of genome-wide association studies (GWAS), the need to develop the bioinformatics infrastructure and the contribution of structural variation to human genetic disease.

Published
2008
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2. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

Author

Rothman N, Garcia-Closas M, Chatterjee N, Malats N, Wu X, Figueroa JD, Real FX, Van Den Berg D, Matullo G, Baris D, Thun M, Kiemeney LA, Vineis P, De Vivo I, Albanes D, Purdue MP, Rafnar T, Hildebrandt MA, Kiltie AE, Cussenot O, Golka K, Kumar R, Taylor JA, Mayordomo JI, Jacobs KB, Kogevinas M, Hutchinson A, Wang Z, Fu YP, Prokunina-Olsson L, Burdett L, Yeager M, Wheeler W, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned A, Andriole G Jr, Grubb R 3rd, Black A, Jacobs EJ, Diver WR, Gapstur SM, Weinstein SJ, Virtamo J, Cortessis VK, Gago-Dominguez M, Pike MC, Stern MC, Yuan JM, Hunter DJ, McGrath M, Dinney CP, Czerniak B, Chen M, Yang H, Vermeulen SH, Aben KK, Witjes JA, Makkinje RR, Sulem P, Besenbacher S, Stefansson K, Riboli E, Brennan P, Panico S, Navarro C, Allen NE, Bueno-de-Mesquita HB, Trichopoulos D, Caporaso N, Landi MT, Canzian F, Ljungberg B, Tjonneland A, Clavel-Chapelon F, Bishop DT, Teo MT, Knowles MA, Guarrera S, Polidoro S, Ricceri F, Sacerdote C, Allione A, Cancel-Tassin G, Selinski S, Hengstler JG, Dietrich H, Fletcher T, Rudnai P, Gurzau E, Koppova K, Bolick SC, Godfrey A, Xu Z, Sanz-Velez JI, D García-Prats M, Sanchez M, Valdivia G, Porru S, Benhamou S, Hoover RN, Fraumeni JF Jr, Silverman DT, and Chanock SJ

Subjects
Arylamine N-Acetyltransferase genetics, Arylamine N-Acetyltransferase metabolism, Chromosome Mapping methods, Europe epidemiology, Family, Female, Humans, Incidence, Male, Neoplasm Staging, Risk Assessment, Risk Factors, Sex Characteristics, Smoking adverse effects, Spain epidemiology, United States epidemiology, Urinary Bladder Neoplasms epidemiology, Urinary Bladder Neoplasms pathology, Chromosomes, Human, Pair 18 genetics, Chromosomes, Human, Pair 2 genetics, Chromosomes, Human, Pair 22 genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Urinary Bladder Neoplasms genetics
Abstract

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis.

Published
2010
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3. Hair dye use is not associated with risk for bladder cancer: evidence from a case-control study in Spain.

Author

Kogevinas M, Fernandez F, Garcia-Closas M, Tardon A, Garcia-Closas R, Serra C, Carrato A, Castano-Vinyals G, Yeager M, Chanock SJ, Lloreta J, Rothman N, Real FX, Dosemeci M, Malats N, and Silverman D

Subjects
Aged, Case-Control Studies, Genotype, Humans, Odds Ratio, Risk Factors, Spain epidemiology, Urinary Bladder Neoplasms epidemiology, Hair Dyes adverse effects, Urinary Bladder Neoplasms chemically induced
Abstract

An increased bladder cancer risk has been suggested among users of hair dyes. We evaluated this association among females in a hospital-based case-control study in Spain (152 female incident cases, 166 female controls). The effect of hair dye use was also evaluated among potentially susceptible subgroups defined by NAT1, NAT2, CYP1A2, GSTM1, GSTT1 and GSTP1 genotypes. Use of any hair dye (OR=0.8, CI 0.5-1.4) or of permanent hair dyes (OR=0.8, CI 0.5-1.5) was not associated with increased risk. Small non-significant increases in risks were observed in a lagged analysis that ignores exposures within ten years of diagnosis (OR=1.3, CI 0.8-2.2). No trend in risk with increasing exposure was seen for duration of use, average use or cumulative use. None of the polymorphisms examined significantly modified the hair dye associated risk. Overall, this study does not support an association between hair dye use and bladder cancer.

Published
2006
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