1. Are Obesity and Physical Fitness Associated with Cardiovascular Disease Risk in Adolescents with Down Syndrome? The Longitudinal UP&DOWN Study
- Author
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Izquierdo-Gomez, Rocio, Esteban-Cornejo, Irene, Cabanas-Sanchez, Veronica, Marcos, Ascensión, Gómez-Martínez, Sonia, Castro-Piñero, José, and Veiga, Óscar L.
- Abstract
Introduction: The aims of this study were to examine cross-sectional, and longitudinal association of different measures of obesity and physical fitness with cardiovascular disease (CVD) risk factors in adolescents with Down syndrome. Methods: Longitudinal analysis included 90 adolescents with Down syndrome. Obesity and physical fitness were measured following the ALPHA battery. Blood pressure and blood samplings (glucose, total cholesterol, high-density lipoprotein cholesterol, and serum lipid triglycerides levels (mg/dl) were determinated. Results: In cross-sectional analyses, obesity was positively associated with single CVD risk factors and CVD risk factor index (all p < 0.05). In the prospective analyses, obesity was not associated with single CVD risk factors, but components of physical fitness at baseline impact in some single CVD risk factors (all p < 0.05). Conclusion: Obesity might be more strongly related to current cardiovascular-health, while components of physical fitness might be more related to future cardiovascular-health in adolescents with Down syndrome. [This article was written on behalf of the UP&DOWN Study Group.]
- Published
- 2023
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