1. Diversonol and blennolide derivatives from the endophytic fungus Microdiplodia sp.: absolute configuration of diversonol.
- Author
-
Siddiqui IN, Zahoor A, Hussain H, Ahmed I, Ahmad VU, Padula D, Draeger S, Schulz B, Meier K, Steinert M, Kurtán T, Flörke U, Pescitelli G, and Krohn K
- Subjects
- Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Antifungal Agents chemistry, Antifungal Agents pharmacology, Bacillus megaterium drug effects, Basidiomycota drug effects, Crystallography, X-Ray, Escherichia coli drug effects, Legionella pneumophila drug effects, Lycium microbiology, Microbial Sensitivity Tests, Molecular Structure, Spain, Xanthones chemistry, Xanthones pharmacology, Anti-Bacterial Agents isolation & purification, Antifungal Agents isolation & purification, Ascomycota chemistry, Xanthones isolation & purification
- Abstract
Chemical investigation of the fungal strain Microdiplodia sp. isolated from the shrub Lycium intricatum led to the isolation of four new compounds: a hexahydroxanthone (2), a 2,3-dihydrochroman-4-one (3), a 7-oxoxanthone derivative (4), and a 1,4-oxazepan-7-one (5). The relative configurations of the new compounds were determined by intensive NMR investigations, notably NOESY experiments at different temperatures. The absolute configurations of the well-known fungal metabolite diversonol (1) and of other xanthone derivatives (3, 4) were established by means of TDDFT ECD calculations. Most of the metabolites were biologically active, with antibacterial activity against Legionella pneumophila and/or antifungal activity against Microbotryum violaceum.
- Published
- 2011
- Full Text
- View/download PDF