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Start Over Author "Siswantoro, H." Region southeast asia
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1. Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open- label randomised comparison.

Author

Ratcliff, A., Siswantoro, H., Kenangalem, E., Maristela, R., Wuwung, R.M., Lailand, F., Ebsworth, E.P., Anstey, N.M., Tijtra, E., and Price, R.N.

Subjects
*ANTIMALARIALS, *MULTIDRUG resistance, *DRUG resistance, *PLASMODIUM vivax, *PLASMODIUM falciparum, *MALARIOTHERAPY, *PREVENTIVE medicine
Abstract

The authors compare the safety and efficacy of two fixed-dose artemisinin combinations for Plasmodium vivax infections for which chloroquine-resistant strains have emerged. Malaria caused by drug-resistant P. falciparum and P. vivax is a public health burden in southeast Asia. Both artemisinin combinations were safe and effective as therapeutics for multidrug-resistant uncomplicated malaria. Dihydroartemisinin-piperaquine was a better post-treatment prophylactic agent than artemether-lumefantrine in the reduction of recurrences and reinfections.

Published
2007
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