1. Treatment‐related cardiovascular events in patients with non–small cell lung cancer: Evidence from real‐world data with a competing risks approach.
- Author
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Tran, Thi‐Ngoc, Lee, Sanghee, Kim, Hak Jin, Lee, Youngjoo, Tu, Thao Minh, Choi, Jin‐Ho, Song, Jae Won, and Cho, Hyunsoon
- Subjects
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NON-small-cell lung carcinoma , *PNEUMONECTOMY , *CEREBROVASCULAR disease , *COMPETING risks , *CARDIAC patients , *ATRIAL flutter , *CORONARY disease , *CEREBRAL embolism & thrombosis - Abstract
Background: Understanding cancer treatment–related cardiovascular (CV) events is important for cancer care; however, comprehensive evaluation of CV events in patients with lung cancer is limited. This study aimed to assess the cumulative incidence and associated risks of various CV event types in patients with non–small cell lung cancer (NSCLC). Methods: A total of 7868 individuals aged 40 years and older, recently diagnosed with NSCLC (2007–2018), were assessed with data obtained from the National Cancer Center, Korea. This study included nine types of CV events. A 2‐year cumulative incidence function (CIF) of CV events was estimated, with death as a competing event. The associated risks were assessed by subdistribution hazard ratio (sHR) in the Fine–Gray competing risks model. Results: CV events were observed in 7.8% of patients with NSCLC, with the most frequently observed types being atrial fibrillation and flutter (AF) (2.7%), venous thromboembolic disease (2.0%), and cerebrovascular disease (CeVD) (1.5%). Overall, all CV events were highest in the group treated with systemic therapy (CIF, 10.6%; 95% confidence interval [CI], 9.5%–11.8%), followed by those treated with surgery (CIF, 10.0%; 95% CI, 8.6%–11.6%); the incidence of AF (CIF, 5.7%; 95% CI, 4.6%–7.0%) was highest in patients treated with surgery. Individuals treated with systemic therapy were found to exhibit a higher CeVD risk than those treated with surgery (sHR, 4.12; 95% CI, 1.66–10.23). Among the patients who underwent surgery, those with lobectomy and pneumonectomy had a higher AF risk (vs. wedge resection/segmentectomy; sHR, 7.79; 95% CI, 1.87–32.42; sHR, 8.10; 95% CI, 1.60–40.89). Conclusions: These findings revealed treatment‐related CV event risks in patients with NSCLC, which suggests that the risk of AF in surgery and CeVD in systemic therapy should be paid more attention to achieve a better prognosis and improve cancer survivorship outcomes. Plain Language Summary: Atrial fibrillation and flutter (AF) is the most common cardiovascular event, particularly at a high risk in patients with non–small cell lung cancer (NSCLC) undergoing surgery.Patients receiving surgery with poor performance status, diagnosed with regional stage, and undergoing lobectomy or pneumonectomy are at a high risk of AF.Systemic/radiotherapy is associated with cerebrovascular and ischemic heart disease in patients with NSCLC. This study revealed that cardiovascular events occurred in approximately 8% of patients with non–small cell lung cancer during 2‐year treatment periods, with atrial fibrillation and flutter, venous thromboembolic disease, and cerebrovascular disease being the most common types. The findings further emphasize the importance of monitoring atrial fibrillation in patients receiving surgery and cerebrovascular disease in those treated with systemic therapy to enhance cancer care and survivorship outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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