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Background: Post-operative delirium (PD) is a common post-operative complication with significant clinical and financial impacts on patients. Erythropoietin (EPO), a multi-functional glycoprotein hormone, exhibits erythropoietic and non-erythropoietic anti-inflammatory properties. This study aimed to determine the role of perioperative EPO administration in the development of postoperative delirium in older adult patients undergoing total joint arthroplasty. Methods: Seventy-one patients (> 65 years old) scheduled for total joint arthroplasty were randomly assigned to two groups: EPO-treated (EPO, n = 35) and placebo (control, n = 36). All patients completed the Mini Mental State Examination (MMSE) pre-operatively and on post-operative day (POD) 2. The confusion assessment method (CAM) was used to assess the patients until discharge (POD 5). Serum C-reactive protein (CRP) and inflammatory cytokine levels were measured and compared pre- and post-operatively. The development of delirium and cognitive dysfunction was evaluated post-operatively. Results: One patient in the control group developed delirium on POD 2 (3.2%), whereas no patient in the EPO group developed PD (0% vs. 3.2%, p = 0.500). Post-operatively there was no significant difference in MMSE scores between groups. Both groups showed increases in pro- and anti-inflammatory cytokine levels, with no significant differences. Similarly, CRP levels, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) showed no intergroup differences in post-operative inflammatory responses. Conclusions: Perioperative EPO reduced the incidence of post-operative delirium, although not statistically significant, with no differences in post-operative cognitive function and inflammatory responses. Trial registration: The trial was registered on December 12, 2023 at http//clinicaltrials.gov, registration number NCT06178835. [ABSTRACT FROM AUTHOR]

Background/Objectives: The aim of this study was to investigate the effect of a custom neck collar with negative sensory feedback for the treatment of torticollis that was previously unresponsive to conservative or surgical treatment. Methods: Twenty-four children diagnosed with unresponsive or intractable torticollis were enrolled in this two-stage, single-arm study. The ipsilateral aspect of the orthosis is adjustable in height and designed to provide support between the clavicle and the mandibular angle on the tilted side. In stage 1 (the adjustment period), the orthosis with a smooth surface was applied for 2 h per day for 3 months. In stage 2, a rough surface with a hook-and-loop fastener (Velcro©) was attached to the collar, and it was worn for a further 2 h a day for 3 months. Twenty children (mean age 63.95 ± 13.44 months) were included in the analysis. Results: The mean torticollis angle was 17.60 ± 5.65° (mean ± SD) at baseline; 14.15 ± 3.62° directly after stage 1; and 6.00 ± 3.67° directly after stage 2 (X2 = 36.685, df = 19, p = 0.000). Conclusions: This study demonstrated the feasibility, therapeutic effect, and safety of a novel tactile feedback orthosis for the treatment of children with torticollis. The use of a custom neck collar with negative sensory feedback may be a viable therapeutic option for the treatment of unresolved or intractable torticollis. [ABSTRACT FROM AUTHOR]

Clinical practice is an important educational tool for nursing students, and their emotions during clinical practice should be accurately understood. This study aimed to develop and verify the validity and reliability of a clinical practicum transition shock scale (CPT-shock) to measure Korean nursing students' emotional responses when transitioning from a theoretical learning process to clinical practice. This research design was a methodological study and the content, construct, criterion validity, and reliability of the items were verified. Content validity was evaluated by seven experts. The preliminary survey was conducted on 24 nursing students, and the factor analysis was conducted on 331 nursing students in various regions of Korea. Confirmatory factor analysis confirmed the model fit (χ2/df = 1.741, GFI = 0.930, AGFI = 0.902, NFI = 0.869, TLI = 0.923, CFI = 0.938, RMR = 0.035, RMSEA = 0.047) and established discrimination and convergence validity. Positive and negative correlations were found with existing transition shock (r = 0.779) and clinical practice adaptation (r = −0.505), respectively (p < 0.001), thus establishing criterion validity. The reliability was good, with a Cronbach's α of 0.85. The clinical practicum transition shock scale reflects nursing students' practice environment and is expected to accurately measure nursing students' unique emotional shock. [ABSTRACT FROM AUTHOR]

Four species of Erythrotrichia (E. biseriata, E. reflexa, E. tetraseriata, E. carnea) have been reported in Korea, but phylogenetic studies have not been conducted on them. We analyzed two newly collected Erythrotrichia isolates using rbcL DNA sequences and determined their species status using four DNA-based species delimitation methods. One isolate (KNU-1) grouped with E. carnea in three methods: Assemble Species by Automatic Partitioning, both single-threshold and multiple-threshold general mixed yule coalescent, but grouped as a distinct species in the statistical parsimony network analysis. A second isolate (KNU-2) was considered a distinct species in all the above species-delimitation methods. We propose the name, Erythrotrichia johnawestii sp. nov., for this new species. The new species was different from E. carnea in lacking a thick outer cell wall layer and with a smaller cell size. Mature monosporangia produced raised openings that released monospores. Cell walls were not detected in newly released monospores but began to appear when the spore attached to the substratum and produced rhizoids. Sexual reproduction was not observed during the four-year culture period. [ABSTRACT FROM AUTHOR]

Since Russia invaded Ukraine in February 2022, there has been an urgent need to provide mental healthcare and share various practices for Ukrainian war refugees. This study urgently focuses on the need for art therapy to support the mental health of Ukrainian refugees, Koryo-saram, who are staying in the Republic of Korea due to the wartime emergency. It also examines the impact of art therapy intervention on anxiety and subjective stress. The single-session art therapy with the 54 Koryo-saram refugees aged 13-68 showed the effectiveness of the art therapy intervention. The results indicate that GAD-7 (t = 3.092, p = 0.003) and SUDs (t = 3.335, p = 0.002) were statistically significant within the intervention group. In addition, satisfaction assessments of the qualitatively analyzed participants showed that Ukrainian Koryo-saram had a positive experience of art therapy. Therefore single-session art therapy in this study demonstrated the efficacy of art therapy for the anxiety and subjective distress of Ukrainian Koryo-saram refugees. This result suggests that the intervention of art therapy as immediate mental healthcare for refugees facing war could benefit the mental health of Koryo-saram refugees. [ABSTRACT FROM AUTHOR]

Background: Phase I of the Korean Undiagnosed Diseases Program (KUDP), performed for 3 years, has been completed. The Phase I program aimed to solve the problem of undiagnosed patients throughout the country and develop infrastructure, including a data management system and functional core laboratory, for long-term translational research. Herein, we share the clinical experiences of the Phase I program and introduce the activities of the functional core laboratory and data management system.Results: During the program (2018-2020), 458 patients were enrolled and classified into 3 groups according to the following criteria: (I) those with a specific clinical assessment which can be verified by direct testing (32 patients); (II) those with a disease group with genetic and phenotypic heterogeneity (353 patients); and (III) those with atypical presentations or diseases unknown to date (73 patients). All patients underwent individualized diagnostic processes based on the decision of an expert consortium. Confirmative diagnoses were obtained for 242 patients (52.8%). The diagnostic yield was different for each group: 81.3% for Group I, 53.3% for Group II, and 38.4% for Group III. Diagnoses were made by next-generation sequencing for 204 patients (84.3%) and other genetic testing for 35 patients (14.5%). Three patients (1.2%) were diagnosed with nongenetic disorders. The KUDP functional core laboratory, with a group of experts, organized a streamlined research pipeline covering various resources, including animal models, stem cells, structural modeling and metabolic and biochemical approaches. Regular data review was performed to screen for candidate genes among undiagnosed patients, and six different genes were identified for functional research. We also developed a web-based database system that supports clinical cohort management and provides a matchmaker exchange protocol based on a matchbox, likely to reinforce the nationwide clinical network and further international collaboration.Conclusions: The KUDP evaluated the unmet needs of undiagnosed patients and established infrastructure for a data-sharing system and future functional research. The advancement of the KUDP may lead to sustainable bench-to-bedside research in Korea and contribute to ongoing international collaboration. [ABSTRACT FROM AUTHOR]

Art therapy is useful for immigrant youth to reduce depression, anxiety and stress through visualised images. This study determined indications of psychological outcomes, acceptability and satisfaction of art therapy among Korean immigrant youth. A quasi-experiment (one-group pre-, post-test) design, with 25 young people (13–24 years old) in the Republic of Korea receiving five weekly sessions of art therapy from November 2020 to March 2021. Patient Health Questionnaire-9, Generalised Anxiety Disorder-7 and Perceived Stress Scale were used as psychological measurements to determine the programme's indications of outcomes; acceptability and satisfaction were measured. The level of depression severity and perceived stress level was improved and the level of depression severity was maintained at the three-month follow-up as a result of art therapy. According to the acceptance rate, 79.2% found it useful and 78.2% found it enjoyable. Art therapy for Korean immigrant youth has the promising result. However, extensive study is necessary to rigorously examine its effectiveness and develop interventions suitable across cultures. This study showed that art therapy could be an acceptable and efficacious therapeutic mental health intervention for immigrant youth who face challenges with verbal communication and undergo acculturative stress. This study was conducted to examine the outcomes of psychological measurements, and acceptability of, as well as satisfaction with, five sessions of art therapy delivered to 25 Korean immigrant youths (13–24 years old). The study found positive changes perceived by immigrant youths. The levels of depression severity and perceived stress were improved, and the reduced depression severity was maintained at the three-month follow-up. The study also reported art therapy as 79.2% found it useful and 78.2% found it enjoyable, contributing to their psychological stability. Overall, art therapy could be an acceptable and efficacious therapeutic mental health intervention for immigrant youths, who face challenges with verbal communication and experience acculturative stress. [ABSTRACT FROM AUTHOR]

Background: Rubinstein–Taybi syndrome (RSTS) is a rare congenital malformation syndrome with clinical characteristics such as hypertrichosis, high arched eyebrows, large beaked nose, and broad thumbs and halluces. RSTS patients showed intellectual disability and health problems such as short stature, ophthalmologic abnormalities, congenital heart defects, genitourinary defects, and variable types of tumors. Although mutations in CREBBP and EP300 genes are associated with RSTS features, genetic causation is still unknown in 30% of patients. Methods: We present clinical and molecular genetic characteristics of 25 unrelated Korean patients clinically diagnosed with RSTS. Sanger sequencing analysis and multiplex ligation‐dependent probe amplification for CREBBP in 25 patients and exome sequencing of CREBBP‐negative cases were performed in nine patients successively. Results: Causative variants were identified in 20 (80%) patients: 16 (64%) in CREBBP and 4 (16%) in EP300. All the identified variants predict protein truncation (11 frameshift, 2 nonsense, 1 splicing‐site, and 6 large intragenic deletions); there are no repeatedly identified sequence variants. Four of the CREBBP and all four EP300 variants are novel. Intellectual disability was noted in 24/25 patients (96%); no difference was found between CREBBP and EP300 groups. One patient with a CREBBP variant (4%) had malignant tumor. Conclusions: To date, this is the largest cohort of patients with RSTS including EP300‐related patients in Korea. Future large‐scale studies to find genetic mutation of molecularly unsolved patients and long‐term prospective studies are required to validate our results. [ABSTRACT FROM AUTHOR]

The current study was conducted to investigate mental health levels in Korean adults during the coronavirus 2019 (COVID-19) pandemic and determine their predictors. The study was conducted online, and 334 adults from 14 locations in Korea participated. Data collection was conducted from May 19 to May 24, 2020, using a questionnaire consisting of general and COVID-19–related characteristics, perceived physical health, individual and community resilience, and mental health. For data analysis, descriptive statistics, The current study was conducted to investigate mental health levels in Korean adults during the coronavirus 2019 (COVID-19) pandemic and determine their predictors. The study was conducted online, and 334 adults from 14 locations in Korea participated. Data collection was conducted from May 19 to May 24, 2020, using a questionnaire consisting of general and COVID-19–related characteristics, perceived physical health, individual and community resilience, and mental health. For data analysis, descriptive statistics, t test, one-way analysis of variance, and hierarchical regression were used. In cases where women were more vulnerable to mental health problems and gender was controlled, regression analysis showed that individual resilience (β = −0.212, p < 0.001), perceived physical health (β = −0.160, p = 0.004), and community resilience (β = −0.119, p = 0.031) had an effect on mental health. Following the COVID-19 pandemic, communities should screen groups vulnerable to mental health problems and develop an integrated mental health program that incorporates predictors of mental health difficulties. [Journal of Psychosocial Nursing and Mental Health, 59(3), 18–27.] [ABSTRACT FROM AUTHOR]

This study reviewed new concept waterproofing performance gradation to respond to the limit of unified single standard performance standard used in each country from the past until now. This study was carried out using the standard test data from 34 products tested and evaluated by Korea's national quality test institution for 2 years (2018~2019) based on national standard specification (KS F 4934, Self-Adhesive Rubberized Asphalt Sheet). Major proposal contents utilized the result values of 9 waterproofing performance evaluation criteria included in the national standard specification. Major study contents and results are as follows. Existing widely used domestic and overseas standard grading (Stanine, Sten Scores, Grade 5 Scale, energy consumption efficiency, and other grading) theories were investigated and analyzed. Based on the analysis contents, standard Grade 5 Scale system suitable for waterproofing material performance grading was selected and applied. Grade sections were set according to the application ratio for each grade section of Grade 5 Scale (grade 1 with 10%, grade 2 with 20%, grade 3 with 40%, grade 4 with 20% and grade 5 with 10%). According to the set sections, performance grades were derived for 9 test criteria of 34 products. Section setting standard for grade section was derived centered on the performance result values of 9 criteria. As a result, average value of waterproofing performance of each of 9 test criteria for 34 products was verified to have 1.2 times to 7.52 times higher performance value than the minimum quality standard (based on grade 5). Such results sufficiently showed the limit of the current unified single standard performance application. Also, as a solution for waterproofing quality degradation problem, possibility to apply the waterproofing performance grading of this study was verified. Therefore, through this study, it is decided that new concept quality standard to pursue future waterproofing industry development can be set, quality reinforcement is possible by performance grading for each product and sustainable waterproofing performance maintaining effect at the waterproofing construction site can be expected with the use of such gradation. [ABSTRACT FROM AUTHOR]

Previous studies have investigated the predictors for home discharge without considering stroke severity. To develop a practical assessment tool that predicts home discharge for moderate stroke patients after subacute rehabilitation therapy in the tertiary hospitals. Stroke patients with National Institutes of Health Stroke Scale scores of 6 to 13 were included in this prospective cohort study. Various demographic, clinical, and functional factors were analyzed as potential predictive factors. A weighted scoring model was developed through the following three-step process: 1) selection of the factors by logistic regression analyses, 2) development of a weighted scoring model, and 3) validation of the generalizability of the model. The home discharge rate was 51% (n = 372), and the overall mean length of stay of hospitalization was 32.5 days. 1) The Cognitive Functional Independence Measure, 2) the Functional Ambulation Categories, 3) the modified Charlson Comorbidity Index, and 4) marital status were independent predictors of home discharge. The coefficient value for marital status was adjusted to 1 in the scoring system, and the values of the other parameters were proportionally converted to the nearest integer. Possible total scores ranged from 0 to 13 in the model, with a higher score indicating a higher probability of home discharge. With a cutoff point of 7, this model showed 87.0% sensitivity and 86.2% specificity (area under the curve = 0.90). This novel assessment tool can be useful in predicting home discharge after subacute rehabilitation of moderate stroke patients. [ABSTRACT FROM AUTHOR]

Background: This study developed a structural model of the professional socialization of nursing students with clinical practice experience and tested its validity based on Meleis's transition theory. Method: Participants were third- and fourth-year nursing students with at least one semester of clinical experience. Cross-sectional data from 412 participants were analyzed. Results: The goodness of fit of the model was satisfactory. Regarding the differences in educational year, the effects of the clinical learning environment on adaptation to a clinical practicum were not significant for third-year students but were significant for fourth-year students. The effects of clinical practice competency on professional socialization were significant only for fourth-year students. Transition shock and adaptation to clinical practicum paths were significant factors in both groups. Conclusion: Clinical adaptation is important for developing professional socialization in nursing students. Clinical adaptation can be achieved by improving the clinical learning environment and facilitating the development of clinical practice competency. Clinical adaptation is important for developing professional socialization in nursing students. Clinical adaptation can be achieved by improving the clinical learning environment and facilitating the development of clinical practice competency. [[J Nurs Educ. 2020;59(3):133–141.] [ABSTRACT FROM AUTHOR]

Aim: The purpose of this study was to determine whether regionally distributed medial temporal cortex thickness (or hippocampal volume) and frontal lobe volume are independently associated with the onset of Alzheimer's disease (AD) with psychosis. Methods: We identified 26 AD patients with psychosis (AD+P) and 48 AD patients without psychosis (AD−P) from the Memory Impairment Clinic at Pusan National University Hospital in South Korea. They were matched for age, gender, duration of AD, and Clinical Dementia Rating sum of box score. All participants met the National Institute of Neurological and Communication Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association criteria for probable AD. Psychosis was diagnosed according to Jeste and Finkel's proposed diagnostic criteria for psychosis of AD. All participants underwent 3‐T magnetic resonance imaging, and 3‐D magnetization‐prepared rapid gradient echo sequence was acquired for each. The FreeSurfer version 5.1 software package was used to analyze cortical thickness and volume on 3‐D T1‐weighted images. anova was used to investigate the differences in cortical thickness and the volume of the total frontal cortex, total temporal cortex, and subregions of the medial temporal cortex between groups after age, gender, years of education, Clinical Dementia Rating sum of box score, duration of AD, and total intracranial volume were controlled for. Furthermore, we added the total frontal volume as an additional variable to investigate whether the association between the medial temporal cortex and AD+P is independent of the frontal cortex. Results: We found that both left and right hippocampal volume were smaller in AD+P than in AD−P. In particular, there was a significant difference in right hippocampal volume between the AD+P and AD−P groups after total frontal volume was added as an additional variable. Conclusion: We found that more severe hippocampal atrophy is associated with AD+P than with AD−P. In addition, atrophy of the right hippocampus remained significant among AD+P after adjustment for frontal volume. These findings suggest that right hippocampal atrophy is independently associated with AD+P. [ABSTRACT FROM AUTHOR]

This study explores the relationship between Hofstede’s cultural dimensions and public relations practitioners’ perceptions of corporate social responsibility (CSR) in South Korea. The survey on Korean public relations practitioners revealed that, although Hofstede’s dimensions significantly affect public relations practitioners’ perceptions of CSR, social traditionalism values had more explanatory power than cultural dimensions in explaining CSR attitudes. The results suggest that practitioners’ fundamental ideas about the corporation’s role in society seem to be more important than their cultural values to understand public relations practitioners’ CSR attitudes in Korea. [ABSTRACT FROM AUTHOR]

Background: Traditional Korean medicine (TKM) has been employed for the treatment of children with cerebral palsy in Korea; however, the addition of TKM to usual rehabilitation (UR) treatment is hindered by insufficient evidence of clinical improvement with TKM in patients with cerebral palsy. In this study, we will evaluate the effectiveness and safety of integrative medicine rehabilitation (IMR) for cerebral palsy through a randomized controlled clinical study.Methods: Eighty children (2-6 years old) diagnosed with cerebral palsy will be recruited and randomly divided into groups A and B. Patients in group A will receive IMR with UR, while those in group B will receive only UR during weeks 1-12 of the study. IMR includes acupuncture treatment (head and limb acupuncture) three times a week and the administration of herbal medicine (Yukgunza-tang and Yukmijihwang-tang extracts) twice a day in parallel with UR. Evaluations will be conducted at the beginning of the study and at 12 and 24 weeks (follow-up). The primary outcome is the Gross Motor Function Measure-88 score, and the secondary outcomes are the scores for the Goal Attainment Scale, Korean Bayley Scales of Infant Development III, and the Pediatric Quality of Life Inventory, and adverse events.Discussion: This will be the first pragmatic randomized controlled trial to evaluate the efficacy and safety of IMR in children with cerebral palsy in Korea. The results will help to demonstrate if IMR is an effective therapeutic approach for cerebral palsy.Trial Registration: Ministry of Food and Drug Safety 31361 ( http://www.mfds.go.kr ). Registered on 29 June 2017. Clinical Research Information Service KCT0002620 ( https://cris.nih.go.kr/cris/search/search_result_st01.jsp?seq=9819 ). Registered on 29 December 2017. [ABSTRACT FROM AUTHOR]

Objective: The Children's Depression Rating Scale-Revised (CDRS-R) is a valid instrument for the assessment of depressive symptoms in youth, but this measure is yet to be validated in Korea. Thus, the present study aimed to evaluate the validity of the Korean version of the CDRS-R and to determine its factor structures.Methods: This study included 66 youths between 12 and 17 years of age who participated as part of an ongoing study investigating biomarkers of the antidepressant response and suicidal events in depressed youth. At baseline, the participants were assessed using the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime version (K-SADS-PL), CDRS-R, Children's Depression Inventory (CDI), Beck Depression Inventory (BDI), Clinical Global Impressions-Severity (CGI-S), Children's Global Assessment Scale (CGAS), and Child Behavior Checklist (CBCL). Based on their diagnosis, each participant was assessed either five (major depressive disorder [MDD], n = 36) or two (non-MDD, n = 30) more times with the CDRS-R, CDI, BDI, CGI-S, and CGAS; thus, 306 assessments were included in the final analyses of the present study. Pearson's r and Cronbach's α values were used to determine validity and internal consistency, and exploratory factor analysis was performed to determine the factor structures of the Korean version of the CDRS-R.Results: The CDRS-R score was significantly correlated with scores on the K-SADS-PL depression subscale (r = 0.93, p < 0.01), CDI (r = 0.86, p < 0.01), BDI (r = 0.85, p < 0.01), CGI-S (r = 0.84, p < 0.01), and CGAS (r = -0.86, p < 0.01), indicating that this measure has strong criterion validity. In addition, the high correlation of the CDRS-R with the depression subscale of the CBCL (r = 0.67, p < 0.01) and lower correlations with the subscales of the CBCL that assess delinquent behavior, aggressive behavior, and externalizing problem support the discriminant validity of this instrument (rs ≤ 0.50, p < 0.01). Internal consistency was high, as evidenced by a Cronbach's α of 0.91, and the exploratory factor analysis revealed that the Korean version of the CDRS-R comprised three factors as follows: subjective depressed mood, daily functional impairment, and observed depressive affect. These factors differed from those used in previous studies, which were performed with the English version of the CDRS-R.Conclusions: This study of the Korean version of the CDRS-R provides initial promising data regarding its criterion validity, discriminant validity, internal consistency, and factor structures. These properties were significantly strong, which suggests that the Korean version of the CDRS-R is a valid and reliable instrument for the assessment of depressive symptoms in youth. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the efficacy and safety of low-level light therapy in women with primary dysmenorrhea.Method: A multicenter prospective, randomized, double-blind, placebo-controlled clinical trial including patients 18-35 years of age with primary dysmenorrhea was undertaken at two university hospitals in South Korea between October 2011 and September 2012. Patients were randomized using a computer-generated sequence to receive low-level light therapy using the Color DNA-WSF device or to receive placebo treatment with a dummy device. The severity of menstrual pain, assessed using a visual analog scale, was the primary outcome and was evaluated at baseline and during every menstrual cycle for 3 months following treatment. Patients who received more than one application of treatment (with a Color DNA-WSF or placebo device) were included in analyses. Patients and investigators were masked to the treatment assignments.Results: Overall, 44 patients were assigned to each group. At the final study visit, the reduction in scores using a visual analog scale was significantly greater in patients who received low-level light therapy (n=41; 4.34±2.22) than among those in the control group (n=38; 1.79±1.73; P<0.001 when adjusted for age) No serious adverse events occurred.Conclusion: Low-level light therapy could be an effective, safe treatment modality for women with primary dysmenorrhea. Clinical Trials.gov: NCT02026206. [ABSTRACT FROM AUTHOR]

Evidence from cohort studies on the effects of long-term exposure to air pollution on mortality is limited in South Korea, which has high concentration of particles compared to North America, Western Europe, and Japan, and low exposure compared to China. To reduce knowledge gaps between other countries and South Korea, we investigated the association between all-cause, cardiovascular, and respiratory mortality and long-term exposure to PM 10 and, as a surrogate for fine particles from local emission sources, SO 2 and NO 2. Participants comprised 18,220 subjects (97,114.4 person-years) residing in 73 districts of seven major cities of South Korea who were assigned to measurements of fixed-site monitoring stations and followed up. We applied Cox proportional hazard models with time-varying exposure up to three years average of air pollutants. We adjusted for individual and district-level covariates measured at baseline such as age, sex, socioeconomic positions, and health behaviors. We found that hazard ratios of PM 10 and SO 2 for all-cause mortality leveled off over approximately 5 ppb of SO 2 and 35–50 μg/m3 of PM 10. Interquartile range increases of PM 10 (5.05 μg/m3), SO 2 (2.09 ppb), and NO 2 (11.41 ppb) were associated with 14.4% (95% CI: −0.4, 31.4), 18.1% (−4.5, 46.0), and 18.9% (−8.7, 54.7) increases in cardiovascular mortality, respectively. We did not find positive associations for respiratory mortality. The increase in cardiovascular mortality varied by sex (for PM 10 , in females, 27.4% (5.8, 53.5) increase), smoking (in non-smokers, 35.9% (12.7, 64.0) increase), drinking (in drinkers, 24.5% (2.1, 51.8) increase), marital status (in those not married, 23.1% (1.1, 49.9)), employment status (for SO 2 , in those employed, 79.4% (16.1, 177.3) increase), body mass index (in those ≥23, 47.6% (10.4, 97.3) increase), and community deprivation (for PM 10 , in less deprived communities, 21.0% (1.3, 44.4) increase). In summary, long-term exposure to air pollution is associated with mortality risk in South Korea. Our results suggest that the health effect of long-term exposure to air pollution may not be equal by sex, health behaviors and socioeconomic positions. • Long-term exposure to PM 10 and SO 2 is associated with mortality in South Korea. • Our results for cardiovascular mortality reconcile those of previous studies. • This association may differ by sex, health behaviors, and socioeconomic positions. • The health effect of long-term exposure to air pollution may not be equal. [ABSTRACT FROM AUTHOR]