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배경: Human enteroviruses (EVs) are associated with a broad spectrum of diseases, from mild symptoms to neurological ones. To develop effective preventive measures for EV infection, including vaccines, monitoring circulating EVs is very important. Therefore, this study aimed to evaluate the long-term pattern changes in the prevalence, seasonality, and genotype distribution in Korea for 10 years (2011–2020). 방법: Totally, 7,160 specimens (stool, throat swab, skin swab, and cerebrospinal fluid) were collected from patients with suspected EV infections in 10 local hospitals between 2011–2020 in Gwangju, Korea. RNA extraction and real-time reverse transcription polymerase chain reaction using EV-specific probes and primers were performed for EV detection. EV genotyping and phylogenetic analysis were performed using BLAST and the Enterovirus Genotyping Tool. 결과: Among the 7,160 specimens collected, EVs were detected in 3,076 (43.0%). The annual EV detection rate varied. No difference in EV infection by sex was observed, and children aged ≤4 years were susceptible to EV infection; this trend has not changed over time. Overall, 35 different EV types belonging to four different species and rhinoviruses were identified. Although the serotype distribution changed frequently every year, the eight most frequently observed EVs were EV71 (accounting for 13.1% of the cases), CA6 (8.3%), CB5 (7.6%), CA16 (7.6%), CA10 (7.5%), E18 (7.5%), E30 (7.0%), and E11 (5.0%) for 10 years (2011–2020). Predominant EV genotypes by clinical manifestation were CB5 for aseptic meningitis; EV71 for hand, foot, and mouth disease (HFMD) cases; and CA10 for herpangina signs. 결론: Our study provides valuable data that aid the development of vaccines against EV infection and comprehensive disease control in South Korea. Consequently, continuous laboratory surveillance of EVs should be improved to detect the emergence of new EV variants and types. [ABSTRACT FROM AUTHOR]