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Although the importance of proper pharmacological treatment for preventing the relapse/recurrence of anxiety disorders is well known, a real-world data-based study has not been conducted. We aimed to investigate the effect of the initial pharmacological patterns related to continuous treatment and the choice of medication on the relapse/recurrence of anxiety disorders. We used claim data from the Health Insurance Review and Assessment Service, South Korea, of 34,378 adults who received psychiatric medications, including antidepressants, after being newly diagnosed with anxiety disorders. We compared the relapse/recurrence rate in the patients receiving continuous pharmacological treatment with those who discontinued treatment early using Cox's proportional-hazards model. Patients receiving continuous pharmacological treatment experienced a higher risk of relapse/recurrence than those who discontinued treatment. Using three or more antidepressants during the initial treatment period decreased the risk of relapse/recurrence (adjusted hazard ratio (aHR) = 0.229 (0.204–0.256)); however, the combined use of antidepressants from the beginning of treatment increased the risk (aHR = 1.215 (1.131–1.305)). Factors other than continuous pharmacological treatment should be considered to effectively prevent the relapse/recurrence of anxiety disorders. The active use of antidepressants, including switching or adding medications based on progress and frequent follow-up visits during the acute phase, were significantly associated with a reduction in the relapse/recurrence of anxiety disorders. [ABSTRACT FROM AUTHOR]

Background: The Patient Health Questionnaire-9 (PHQ-9) has been standardized in several populations and is widely used in clinical practice and health care. However, it has not been appropriately standardized in the Korean general population, and no normative data have been presented. The aim of this study was to provide the normative data and psychometric properties of the PHQ-9 in the nationally representative population of Korea. Methods: We used the nationwide cross-sectional survey data of Korea from 2014 to 2016. The data of 10,759 individuals aged over 19 years were analyzed in this study. As the distribution of the PHQ-9 scores was not normative, the percentile ranks for raw scores were provided. The survey questionnaires included the PHQ-9, The EuroQol-5 Dimension (EQ-5D), and demographic characteristics. We analyzed the construct validity and internal consistency of the PHQ-9. Results: The normative data of the PHQ-9 were generated according to the sex and different age categories. The correlation coefficient between the sum of the PHQ-9 scores and the EQ-5D index was 0.44, which was moderate. The most appropriate model was the two-factor model with five 'affective-somatic' labeled items and four 'cognitive' labeled items. Cronbach's α for the PHQ-9 was 0.79. Conclusions: Our result supports reliability and validity with two-factor structure of PHQ-9 for measuring depression in the Korean nationally representative population. The Korean normative data on the PHQ-9 according to percentile rank can assist in interpreting and comparing scores with other populations. [ABSTRACT FROM AUTHOR]

Introduction: Schizophrenia (SCZ) is one of the most disabling psychiatric disorders. Genetic factors play an important role in both SCZ liability and its treatment outcome. In the present paper, we investigated the effects of several single nucleotide polymorphisms (SNPs) within ten strong candidate genes involved with antipsychotics (APs) mechanisms of action.Methods: Two independent samples were investigated in the present study. Totals of 176 SCZ subjects and 326 controls of Korean ancestry, and 83 SCZ subjects and 194 controls of Italian ancestry were recruited and genotyped. SCZ risk and other parameters were also investigated.Results: Concerning APs response, only a nominal association with HOMER1 rs3822568 in the Korean sample was found. In the haplotype analysis, rs9801117 C-rs12668837 C-rs4621754 A haplotype within ESYT2 and NCAPG2 genes was associated with APs response in the same sample. As for secondary outcomes, rs7439 within PKDCC and rs12668837 within NCAPG2 were associated with SCZ risk in the Italian sample. In the haplotype analysis, rs2788478 G-rs2657375 T-rs1039621 A within the region between WDR60 and ESYT genes and rs2013 C (ESYT2)-rs6459896 A (NCAPG2) haplotypes were associated with SCZ in the same sample. No association was found in the Korean sample. Finally, our exploratory data suggest a possible modulation of HOMER1, ARC, BDNF, TXNRD2, WDR60, and ESYT2 genes in the APs response to specific symptom clusters.Conclusion: Our results did not support a primary role for the genes investigated in the APs response. On the other hand, our secondary results suggest a possible involvement of NACPG2 and PKDCC in SCZ liability. Finally, our exploratory findings may deserve further investigations in specific studies. [ABSTRACT FROM AUTHOR]

Introduction: Ample evidence suggested a role of sigma-1 receptor in affective disorders since the interaction of numerous antidepressants with sigma receptors was discovered. A recent study on Japanese subjects found a genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with major depressive disorder (MDD). We aimed to evaluate the same polymorphism in both MDD and bipolar disorder (BD) as well as its relationship to response to treatment with antidepressants and mood stabilizers.Methods: A total of 238 MDD patients treated for an acute episode of depression, 132 BD patients in treatment with mood stabilizers for a manic or mixed episode, and 324 controls were genotyped for rs1800866. At discharge, response to treatments was evaluated in MDD and BD patients by the Hamilton Rating Scale for Depression (HRSD) and the Young Mania Rating Score (YMRS), respectively.Results: In our Korean sample, allele frequencies were different from those reported in other Asian and non-Asian populations. The CC genotype was associated with BD and, as a trend, with MDD. No significant effect was observed on response to antidepressants in MDD or mood stabilizers in BD, although the CC genotype was more frequent among BD patients experiencing a mixed episode.Conclusion: The present findings are the first to propose the putative role of genetic variants within SIGMAR1 and sigma-1 receptor in BD. Sigma-1 receptor can modulate a number of central neurotransmitter systems as well as some other signaling pathways (e.g., neurotrophin and growth factor signaling) which are seemingly involved in BD and other mood disorders. [ABSTRACT FROM AUTHOR]

Objectives: The objective of this study was to investigate the risk factors of suicidal ideation and their population attributable fraction (PAF) in a representative sample of the elderly population in Korea. Method: We examined the data set from the Survey of Living Conditions and Welfare Needs of Korean Older Persons, which was conducted by the Korea Institute for Health and Social Affairs (KIHASA) in 2011. In that survey, 10,674 participants were randomly selected from those older than age 65. Simultaneous multivariate logistic regression was used to investigate the risk factors of suicidal ideation in terms of their sociodemographic and health-related variables. Subsequently, the PAF was calculated with adjustment for other risk factors. Results: The weighted prevalences of depression and suicidal ideation were 30.3% and 11.2%, respectively. In multivariate analysis, factors significantly associated with decreased risk of suicidal ideation included old-old age (odds ratio [OR] = 0.66 for 75 to 79 years, OR = 0.52 for 80 to 84 years, OR = 0.32 for older than 85 years), economic status (OR = 0.59 for 5th quintile; more than US$25,700 per year), whereas those associated with increased risk included poor social support (OR = 1.28), currently smoking (OR = 1.42), sleep problems (OR = 1.74), chronic illness (OR = 1.40), poor subjective health (OR = 1.56), functional impairment (OR = 1.45), and depression (OR = 4.36). Depression was associated with a fully adjusted PAF of 45.7%, followed by chronic illness (19.4%), poor subjective health status (18.9%), sleep problems (14.1%), functional impairment (4.9%), poor social support (4.2%), and currently smoking (3.6%). Conclusions: Preventive strategies focused particularly on depression might reduce the impact of suicidal ideation in the elderly population. Also, specific mental health centers focused on the specific needs of the elderly population should be established to manage suicidal risk. [ABSTRACT FROM AUTHOR]

Introduction Around 20% of patients with major depression experience residual symptoms. Ginseng has shown potential antidepressant effects in some animal studies and in patients with stress-related somatic symptoms. Therefore, we investigated the effectiveness and tolerability of Korean Red Ginseng adjuvant treatment in patients with residual symptoms of major depression. Methods In this eight-week prospective study, 35 female outpatients aging from 18 to 65 years (45.1 ± 9.5), who were remitted from major depression with residual symptoms, were given Korean Red Ginseng at doses of 3 g/day. The Depression Residual Symptom Scale ( DRSS) and Montgomery-Åsberg Depression Rating Scale ( MADRS) were administrated to evaluate depressive symptoms. The general severity of symptoms was assessed by a clinician using the Clinical Global Impressions Scale for Severity ( CGI- S). The Depression and Somatic Symptom Scale ( DSSS) was also used to evaluate somatic symptoms in the subjects. This trial is registered at Clinical.gov, number NCT01496248. Results Subjects reported significant decrease in depressive symptoms on the DRSS ( P < 0.05) and MADRS ( P < 0.01) decreased significantly over the eight-week period. The scores on the CGI- S, an objective measurement of symptoms, showed significant improvement in the severity of illness ( P < 0.001). Somatic symptoms on the DSSS also attenuated significantly during the study period ( P < 0.05). Discussion These results suggest that Korean Red Ginseng is efficacious as an adjuvant treatment for patients experiencing residual symptoms of major depression. Future placebo-controlled research is required to confirm our results. [ABSTRACT FROM AUTHOR]

Introduction Delays in mental health service utilization for patients with depression have been observed globally. To elucidate some aspects of delays, age-related associations with a series of variables representing different stages of mental health service use were studied concurrently. Methods A total of 1,433 patients with depression participated in a nationwide Korean Depressive Patient Survey through the collaboration of 70 psychiatric clinics and hospitals. Using logistic and Poisson regression, we investigated whether there is variation in the associations by age. Results Patients with depression in South Korea spent 3.4 years on average before starting a first depression treatment after the onset of depression, and 58% of them entered depression treatment in the first year of onset. Early onset appeared to lower the chance of 'early depression treatment': e.g., adjusted odds ratio ( OR)s for onset age of 40-54, 25-39 and <25 versus ≥55 were 0.65 (95% CI = 0.44, 0.94), 0.36 (95% CI = 0.16, 0.81) and 0.18 (95% CI = 0.06, 0.48), respectively. In contrast, favorable associations of early onset with 'self-recognition as depression' and 'number of nonpsychiatric clinics attended' before visiting psychiatrist were found. Younger cohorts were associated with more positive attitudes toward all mental health utilization measures. Discussion Delays in depression treatment are lengthy in South Korea. Those with early onset are more likely to have delayed depression treatment but are more willing to seek help from a psychiatrist once they sought for the treatment. [ABSTRACT FROM AUTHOR]

To examine the prevalence of the Type D construct using the Korean version of the Type D Personality-14 (DS14) on the Korean youth population and to identify relationships between the Type D construct and other mental health measures. Adolescent participants aged 13-18 years were recruited from 12 schools (7 middle schools and 5 high schools) in Ansan city, located in the southwest area of Gyeonggi-do province, Korea. A total of 4,899 students were assessed with the Korean version of the DS14, Beck depression inventory (BDI), Korean Eppendorf Schizophrenia Inventory (K-ESI), Adolescent Mental health Problem behavior Questionnaire (AMPQ), and Alcohol Use Disorders Identification Test-Korean version (AUDIT-K). We found significant differences in all the measured scales and subscale scores between two groups, those with Type D personality and those without (BDI: p < 0.001, K-ESI: p < 0.001, AMPQ: p < 0.001, AUDIT-K: p < 0.001). When comparing the distributions of the high risk participants identified by the results of BDI, K-ESI, AMPQ, and AUDIT-K between participants with either Type D or non-Type D personality, a significantly higher proportion of high risk participants were in the Type D personality group according to all measures (BDI: p < 0.001, K-ESI: p < 0.001, AMPQ: p < 0.001, AUDIT-K: p < 0.001). In conclusions, Type D adolescents experience various and more severe mental health problems. Type D personality was more related with internalizing symptoms in Korean adolescents. DS14 can be useful in a community mental health program designed for adolescents. [ABSTRACT FROM AUTHOR]

Objectives To investigate whether vitamin D levels are independently associated with visceral obesity, sarcopenia, or sarcopenic obesity. Design Cross-sectional. Setting Population-based sample of elderly adults living in Ansan, Korea. Participants Two hundred sixteen men and 268 women aged 65 and older. Measurements Serum 25-hydroxyvitamin D (25( OH)D) levels, visceral fat area ( VFA) according to abdominal computed tomography scanning, and body composition (body fat percentage, appendicular skeletal muscle mass ( ASM)) using dual-energy X-ray absorptiometry. Visceral obesity was defined as VFA of 100 cm2 or greater and sarcopenia as ASM/height2 more than 1 standard deviation ( SD) below the sex-specific mean of a young reference group. Results The adjusted 25( OH)D level for men was negatively associated with systolic blood pressure, VFA, and body fat percentage but positively associated with ASM. In women, waist circumference, triglyceride levels, and VFA were negatively correlated with 25( OH)D levels. In the joint regression model, VFA and ASM were independently associated with 25( OH)D levels (β = −0.078, P = .01 and β = 0.087, P = .02, respectively) per 1 SD difference in VFA and ASM in men but not women. When participants were categorized according to four visceral obesity and sarcopenia categories, adjusted mean 25( OH)D level was lower in men with visceral obesity than in men without but was not affected by the presence or absence of sarcopenia. Conclusion Greater visceral fat and lower muscle mass were associated with lower 25( OH)D levels in elderly Korean men, suggesting that screening for vitamin D deficiency may be appropriate in older Koreans with visceral obesity or sarcopenia. Sarcopenic obesity as defined according to prespecified criteria did not have an additive association with 25( OH)D levels. [ABSTRACT FROM AUTHOR]

Objective. The present study aimed to investigate whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with bipolar disorder (BD) and they could predict clinical outcomes in in-patients with BD treated with mood stabilizers. Methods. One hundred and thirty-two (132) patients with BD and 170 healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures including Young Mania Rating Scale for patients with BD were recorded. Statistical significance was set at the 0.005 level in order to reduce the likelihood of false positive results. Results. We failed to show an evidence for a possible association of GRIA1, GRIA2 and GRIA4 with BD patients, in terms of influences on diagnosis and treatment outcomes, although this was the first study to explore the influence of such genes for bipolar disorder. Conclusion. Our results suggest that 17 SNPs within GRIA1, GRIA2 and GRIA4 may not be associated with the development and treatment outcomes in BD. However, taking into account that the several limitations of our study including the moderately small sample size of our study, our findings should be considered with caution and further research is needed to draw more definitive conclusions. [ABSTRACT FROM AUTHOR]

Objectives To examine the relationship between depression and various components of body composition, including fat and muscle, in elderly Koreans. Design A cross-sectional sample of a longitudinal cohort from the Ansan Geriatric ( AGE) Study. Setting Elderly people living in urban area (Ansan City, South Korea). Participants Eight hundred thirty-six participants (378 male, 458 female) aged 60 and older were recruited from April 2006 to January 2008. Measurements Depressive symptoms were examined using the Korean version of the 30-item Geriatric Depression Scale ( KGDS). Participants taking antidepressant medications or with a KGDS score of 14 or greater were classified as having depression. Abdominal visceral fat area ( VFA) and subcutaneous fat area were assessed using single-slice computed tomography, and appendicular skeletal muscle mass ( ASM) and percentage body fat (% BF) were determined using whole-body dual-energy X-ray absorptiometry. Results Elderly men with depression had a lower ASM than those without depression ( P = .01) after adjusting for age, body weight, and height. In men, the risk of depression was lower with higher body mass index ( BMI) (odds ratio ( OR) per 1-standard deviation ( SD) increase = 0.70, 95% confidence interval ( CI) = 0.51-0.96) after adjusting for all confounding variables and higher ASM ( OR per 1- SD increase = 0.49; 95% CI = 0.29-0.85) after controlling for age, height, and weight. Similarly, depression was negatively associated with BMI in women ( OR per 1- SD increase = 0.73; 95% CI = 0.56-0.95). Waist circumference, % BF, and VFA were not consistently associated with depression in men or women. Conclusion Depression in elderly Koreans is associated with low body mass and sarcopenia, especially in men. [ABSTRACT FROM AUTHOR]

Objective. The present study explored whether d-amino acid oxidase activator ( DAOA) variants were associated with schizophrenia and whether they could predict the clinical outcomes of patients treated with various antipsychotics. Methods. Two hundred and twenty-one (221) patients with schizophrenia and 170 psychiatrically healthy controls were genotyped for seven DAOA single-nucleotide polymorphisms (SNPs) (rs3916966, rs3916967, rs2391191, rs3916968, rs7139958, rs9558571 and rs778293). We also administered baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), to patients with schizophrenia. Results. None of the SNPs under investigation was associated with the development of schizophrenia. However, the rs7139958 AA and rs9558571 TT as well as the rs7139958 A and rs9558571 T genotypes were associated with higher scores on the PANSS positive subscale among patients with schizophrenia, possibly reflecting their greater susceptibility to the development of more severe positive symptoms. No other allele, genotype, or haplotype under investigation was significantly associated with any of the clinical parameters, including clinical improvement, in patients with schizophrenia. Conclusion. Our results suggested that rs7139958 and rs9558571 SNPs may be associated with more severe baseline positive symptoms in patients with schizophrenia. However, further research is needed to draw more definitive conclusions given the limitations of our study. [ABSTRACT FROM AUTHOR]

Abstract: The mini-mental state examination (MMSE) is a brief global instrument used to assess cognitive abilities, and has been translated into the K-MMSE. The clinical value of the K-MMSE is restricted by the small amount of normative data available, especially for the elderly population. We investigated the population-based data of K-MMSE scores to obtain the norms specific for the sociodemographic characteristics of elderly Koreans. The K-MMSE was applied to a cognitively normal sample of 977 subjects aged 60–84 years in Ansan, South Korea. We determined whether the sociodemographic characteristics were related to the K-MMSE scores and calculated the norms. The K-MMSE score was significantly associated with age, gender, and level of education, and this result was used to develop normative data with age, gender, and educational strata. The normative data based on age, gender, and level of education presented here are suitable for clinical use. [Copyright &y& Elsevier]

Numerous studies have highlighted the significant impact of disasters on mental health, often leading to psychiatric disorders among affected individuals. Timely identification of disaster-related mental health problems is crucial to prevent long-term negative consequences and improve individual and community resilience. To address the limitations of prior research that has focused solely on isolated incidents, we analyzed the impact of a recurring Halloween event in Itaewon, South Korea, which culminated tragically in a crowd crush incident in 2022. We conducted sentiment analysis on big data from Korean Twitter to gauge the impact of this disaster on public sentiment. We collected tweets 2 weeks before and after the annual festival from 2020 to 2022, allowing for the consideration of variability across years and days before the disaster. Using a pre-trained RoBERTa neural network model fine-tuned with public sentiment datasets, we categorized tweets into seven pre-defined emotional categories: Anger, sadness, happiness, disgust, fear, surprise, and neutrality. These sentiments were then analyzed as daily time-series data. The overall tweet volume across all sentiment categories increased, particularly showing an increase in the number of tweets indicating "Sadness" in 2022 compared with that in previous years. Post-disaster, a substantial increase was noted in the proportion of tweets expressing "Sadness" and "Fear." This trend was confirmed by Seasonal Autoregressive Integrated Moving Average with Exogenous Regressor models. Notably, there was an increase in the number of tweets expressing all sentiments, including "Happy." However, significant changes in proportions were observed only in tweets categorized as expressing "Sadness" [0.046 (95% CI: 0.024–0.068, P < 0.0001)] and "Fear" [0.033 (95% CI: 0.014–0.051, P < 0.0001)]. Our study demonstrates the feasibility of using sentiment data from social media, combined with sentiment classification, to assess distinct public mental health features following disasters. This approach provides valuable insights into the emotional impact of each event. • A longitudinal study of social media sentiments after a disaster is crucial. • Examining the entire emotional spectrum is a novel approach in disaster psychiatry. • Sadness and fear sentiments significantly increased post-Itaewon disaster. • Social media data has the potential to assess disaster-related mental health. • Interdisciplinary research is crucial in understanding health impacts. [ABSTRACT FROM AUTHOR]

Background: Workplace gender discrimination (WGD) may have long-term negative impacts on female workers' mental health. We aimed to investigate the association between WGD and the prevalence of depressive symptoms using a nationally representative sample of female employees in South Korea.Methods: Data of 3190 adult female employees were obtained from the 2018 nationwide Korean Longitudinal Survey of Women and Families. Women's perception of WGD was assessed using a 6-item questionnaire. Respondents were classified into high, medium, and low levels of WGD according to the 25th and 75th percentile scores. A score of ≥10 on the 10-item version of the Center for Epidemiologic Studies for Depression Scale was defined as having significant depressive symptoms.Results: A high level of WGD was significantly associated with a higher odds ratio (OR) for depressive symptoms compared to the low level (OR = 1.87, 95% confidence interval = 1.45-2.41). In the subgroup analyses, high WGD levels were associated with the highest OR for depressive symptoms in the following subgroups: younger age (19-39 years), those with a college degree, non-standard workers, pink collar workers, those with a workplace size of 10-29 employees, those with high levels of job autonomy, or low levels of emotional labor.Limitations: Causal interpretation is limited owing to the study's cross-sectional design.Conclusions: A high level of perceived WGD was associated with depressive symptoms among female employees. Certain groups of female employees may be particularly vulnerable to the detrimental effects of WGD on depression. [ABSTRACT FROM AUTHOR]

Background: Long working hours can be a risk factor for poor mental health; however, little is known about the potential factors moderating their relation. This study investigates the association between working hours and depressive symptoms, and explores the potential moderating effect of gender, income level, and job status on this association using a nationally representative sample of working population in South Korea.Methods: Data of 7,082 workers aged 19 years or above were obtained from the Korea National Health and Nutrition Examination Surveys (KNHANES) conducted in 2014, 2016, and 2018 in South Korea. Working hours were categorized into 35-39, 40, 41-52, 53-68, and ≥69 hours/week. Depressive symptoms were evaluated using the Patient Health Questionnaire-9 (PHQ-9).Results: Individuals working ≥69 hours/week were more likely to have moderate to severe depressive symptoms compared to those working 40 hours/week. The association between longer working hours and depressive symptoms was especially prominent in female workers, standard wage workers, and workers with low income levels. We observed significant partial mediation pathways between working hours and PHQ-9 scores through both perceived usual stress level and self-rated health in the total sample.Limitations: The cross-sectional design of the study limits causal interpretation of the findings.Conclusion: Working longer than the legal upper limit of 52 hours/week puts workers at a greater risk for depression. Females, low-income workers, and wage workers are more vulnerable to the negative consequences of long working hours on mental health. [ABSTRACT FROM AUTHOR]

Background: Few studies have evaluated the association of depressive symptoms and suicidal ideation with metabolic syndrome (MetS) and its components. This study examined the associations of MetS and its components with suicidal ideation and depression and determined the mediation effect of self-rated health (SRH) on these associations.Methods: This study was conducted using cross-sectional data on 9867 people (aged ≥ 19 years old) collected in 2014 and 2016 from a nationally representative sample of the Korean National Health and Nutrition Examination Survey. The associations of MetS with suicidal ideation and depression were estimated after adjusting for potential confounding factors using logistic regression analyses, and a mediation analysis by Hayes and Preacher was used to estimate the mediation pathway between such associations through SRH.Result: After adjusting for confounding factors, suicidal ideation was associated with MetS. Depressive symptoms and suicidal ideation were associated with two components of MetS: high triglyceride level and high fasting plasma glucose level. In the mediation analysis, we found a significant mediating effect of SRH on the association between high triglyceride level and suicidal ideation.Limitations: We cannot elucidate causal relationships because of the cross-sectional design.Conclusion: Our study provides the implication that a high triglyceride level and elevated fasting plasma glucose level may contribute suicidal risk and depressive symptoms in adults and that SRH may contribute to the development of suicidal ideation in adults via the apparent interaction with one of the components of MetS-high triglyceride level. [ABSTRACT FROM AUTHOR]

Background: Intimate partner violence (IPV) has a serious detrimental effect on mental health outcomes. We aimed to investigate the association of verbal or physical IPV with incidence of depressive symptoms in both married women and men according to the victim-perpetrator role. The potential mediating role of verbal or physical IPV in the association between satisfaction level with family relationships or childhood adversity and the incidence of depressive symptoms in married adults was also explored.Methods: The Korea Welfare Panel Study (KOWEPS) in 2006 and 2007 dataset was analyzed for 9217 married respondents aged 19 years or older. Physical and verbal IPV was assessed according to victim-perpetrator role in 2006. Depressive symptoms were evaluated by the Center for Epidemiologic Studies Depression Scale, 11-item version in 2006 and 2007. Association of IPV with incidental depressive symptoms was investigated with logistic regression analysis fully-adjusted for all potential confounding factors.Results: The bidirectional role of verbal IPV and victimization by physical IPV led to incidence of depressive symptoms in married women. Verbal IPV significantly mediated the association between satisfaction level with the family relationship and incidental depressive symptoms in women.Limitations: We did not investigate the influence of premorbid depressive symptoms on new-onset IPV.Conclusions: This study is the first to demonstrate that gender and the victim-perpetrator role are critical moderating factors in the association between IPV and depressive symptom incidence using a nationally representative sample. [ABSTRACT FROM AUTHOR]

Background: We investigated the interactive effects of depressive symptoms and chronic diseases on health care utilization among elderly people and explored the potential moderating effect of gender and the mediating effect of self-rated health (SRH) on the association between depressive symptoms and health care utilization.Method: We analyzed data from 5223 people aged 60 years or older living in the community from the Korea Welfare Panel Study in 2015. Depressive symptoms were measured using an 11-item version of the Center for Epidemiologic Studies Depression (CES-D-11) Scale and morbidity within 28 disease categories was assessed. Health care utilization was evaluated as the number of outpatient visits (OV), number of hospitalizations (NH), and number of days spent in the hospital (DH) during past year. Hierarchical moderated regression analyses were applied to investigate the interactive effects. We also adopted the mediation analysis method by Hayes and Preacher.Results: A significant interactive effect of CES-D-11 score and chronic disease on OV was found. A positive correlation between CES-D-11 score and OV was only observed in those with chronic disease. Gender had a moderating effect on the association of depression symptoms with OV, NH, and DH among elderly people with chronic disease. SRH had mediating effects on the association of CES-D-11 with OV, NH, and DH only among those with chronic disease.Limitations: The severity or multimorbidity of chronic diseases, which could affect health care utilization among elderly were not considered.Conclusions: We elucidated the complex aspects of the relationship between depressive symptoms and chronic disease and their interactive effects on health care utilization among elderly people, and identified important roles of gender and SRH. [ABSTRACT FROM AUTHOR]

Background: Sickness absence has been regarded as an important indicator of workers' health and work productivity. This study is aimed to evaluate the association between depressive symptoms and sickness absence in workers of South Korea.Methods: We used nationwide cross-sectional survey data from 2889 individuals in the working population aged over 19 years in South Korea. Depressive symptoms were measured using Patient Health Questionnaire-9 (PHQ-9). Those respondents who scored above 10 on PHQ-9 were regarded as having depressive symptoms. Sickness absence was considered a binary variable with an absence of at least 1 day in the past month. The survey instrument contained questions about sociodemographic factors, lifestyle, work-related factors, and chronic illnesses. Logistic regression models were used to find odds ratios and confidence intervals.Results: The prevalence of sickness absence was found to be overall 4.6%. The adjusted odds ratio of sickness absence with depressive symptoms (PHQ-9 score ≥ 10) was 3.63 (Confidence Interval: 2.13-6.20) after controlling of possible confounders. Compared to minimal depressive symptoms (PHQ-9 < 5), the differences between other types of severity of depressive symptoms (mild, moderate, and moderately severe) in terms of mean of all sickness absences were more significant.Limitation: The sickness absence based on the memory of the respondent in this study may result in a recall bias.Conclusions: Incidence of at least 1 day of sickness absence per month increased the risk of depressive symptoms after controlling for the possible confounding factors in general working population. It may be necessary to consider strategies for assessing depression in the workers who take sick leaves. [ABSTRACT FROM AUTHOR]

Abstract: Objective: The purpose of this study was to determine the effect of adjuvant light therapy with antipsychotic treatment in patients with delirium. Methods: Thirty-six patients were referred to the consulting psychiatry division of our hospital for a disturbance in consciousness. The patients were randomized to risperidone (n=16) or risperidone with light therapy (n=20). They were evaluated on Day 0 (baseline) and on Days 1 to 5 with the Delirium Rating Scale (DRS) and the Memorial Delirium Assessment Scale (MDAS). Sleep parameters were measured using a sleep log. Results: Mean DRS and MDAS scores decreased significantly over time in both treatment groups. Risperidone with light therapy group showed a significantly greater decrease in the DRS score than the risperidone-only group (F=2.87, P=.025), but the MDAS score was not significantly different between the two groups. There was a significant improvement in total sleep time (F=2.07, P=.037) and sleep efficiency (F=2.79, P=.029) in the risperidone with light therapy group than in the risperidone-only group. Conclusions: Our results indicate that risperidone with light therapy may be a helpful adjuvant treatment for patients with delirium. Adequately powered studies with a head-to-head comparison design are mandatory to confirm our findings. [Copyright &y& Elsevier]