1. Use of selenium concentration in whole blood, serum, toenails, or urine as a surrogate measure of selenium intake.
- Author
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Longnecker MP, Stram DO, Taylor PR, Levander OA, Howe M, Veillon C, McAdam PA, Patterson KY, Holden JM, Morris JS, Swanson CA, and Willett WC
- Subjects
- Adult, Aged, Aged, 80 and over, Biomarkers blood, Biomarkers urine, Energy Intake, Female, Gas Chromatography-Mass Spectrometry, Humans, Male, Middle Aged, Multivariate Analysis, Neutron Activation Analysis, Nutritional Status, Reproducibility of Results, South Dakota epidemiology, Surveys and Questionnaires, Wyoming epidemiology, Nails chemistry, Nutrition Assessment, Selenium blood, Selenium urine
- Abstract
We examined the validity of using the selenium level in a single biological specimen as a surrogate measure of usual intake. We used data from 77 free-living adults from South Dakota and Wyoming. Subjects provided multiple 1-day duplicate-plate food composites, repeated specimens of blood and toenails, and 24-hour urine collections. We developed a statistical calibration method that incorporated measurement error correction to analyze the data. The Pearson correlation coefficients between selenium intake and a single selenium status measure, after deattenuation to adjust for the effect of within-person variation in intake, were: 0.78 for whole blood, 0.74 for serum, 0.67 for toenails, and 0.86 for urine. We present formulas to estimate the intake of individuals, based on selenium levels in a single specimen of blood, toenails, or urine. In these data, the concentration of selenium in a single specimen of whole blood, serum, or toenails served reasonably well as a measure for ranking subjects according to long-term selenium intake but provided only a rough estimate of intake for each subject.
- Published
- 1996
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