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The current study investigates the extent to which the Minnesota Multiphasic Personality Inventory-Adolescent (MMPI-A) profiles of 196 male adolescents evaluated in a South Carolina detention center could be successfully discriminated from the protocols of 200 male adolescent psychiatric inpatients in three states and 151 dually diagnosed male adolescents. Results showed significant differences in mean T-score values among these three groups of adolescents across a variety of MMPI-A scales and subscales. Results from discriminant function analyses indicate that treatment setting can be predicted effectively from MMPI-A profiles. Beyond the MMPI-A profile differences established for adolescents in these groups, the similarities of adolescents were also noted, particularly in terms of the frequent occurrence of Within-Normal-Limits profiles for adolescents in all groups. Potential directions for future research with the MMPI-A are presented. [ABSTRACT FROM AUTHOR]