Mascarenhas, Rinita, Gandhi, Dorcas B.C., Sesgundo, Jaime Angeles, Babu, Veena, Mani, Vinita Elizabeth, and Sebastian, Ivy Anne
\nBackground: South Asia and Southeast Asia account for more than 40% of the global stroke burden, with differences in stroke risk factors, mortality, and outcomes compared to high-income countries. Sociocultural norms compound the preexisting biological risk differences, resulting in a disproportionate burden of stroke in women in this region. This review summarizes the sex and gender differences across the stroke care continuum in South Asia and Southeast Asia over the past 20 years. Summary: Despite a higher incidence of stroke in men than women in South and Southeast Asia, women have greater stroke severity and poorer outcomes after stroke. Higher levels of premorbid disability and poor physical health at baseline may be contributory. There is a high prevalence of vascular risk factors such as hypertension, dyslipidemia, cardiac sources of embolism, as well as metabolic syndrome and insulin resistance, among the women in this region. Smoking is uncommon among women; however, other forms of smokeless tobacco, such as tobacco leaf and betel nut chewing, are more prevalent, especially in the rural areas in these countries. Women are more likely to have delayed presentations to the hospital due to untimely recognition of stroke symptoms; however, with regards to door-to-needle times or intravenous thrombolysis (IVT) rates, we found equivocal data. Wide gaps exist in stroke awareness and healthcare-seeking behaviors, with women more commonly opting for public hospitals and low-cost wards, more likely to discontinue treatment, and less likely to adhere to poststroke rehabilitation. Key Findings: This review exposes the gender lacunae in stroke service provision across South Asia and Southeast Asia while acknowledging the many knowledge gaps in our understanding. Although the biological risk differences are non-modifiable, educational, policy, and economic measures to mitigate sociocultural barriers are much needed in the region. Sound epidemiological data are needed from more countries to better understand these differences and bridge this gap. It is imperative to advocate and implement policies and programs for stroke care viable for women, cognizant of the gender and cost bias, as well as the interplay of social and cultural structures specific to the regions. In South-and-Southeast Asia, women have greater stroke severity and poorer outcomes after stroke. This is attributable to a higher prevalence of conventional vascular risk factors such as high blood pressure, arrhythmias, and poor lipid regulation as well as hormone related sex-specific factors such as pregnancy, menopause and hormonal replacement therapy which can augment the risk of stroke in women. Women from this region were seen to have similar risk-factor trends with higher frequency of cardiac causes of stroke. Contrary to the rest of the world, tobacco smoking was less common among South-and-Southeast Asian women however, other forms of smokeless tobacco ie consumption of tobacco without burning such as tobacco leaf or betel nut chewing are prevalent especially in countries like Bangladesh and Pakistan. Less frequent forms of stroke like venous strokes are also more common in women in this region. Etiologically, sociocultural practices such as post-partum fluid restriction, dehydration and anemia have been associated although more recently hormonal contraception is also emerging as a cause. Poor awareness, delays in healthcare seeking behaviour, and inadequate availability of stroke services further compounded by disparities augmented by the sociocultural construct of gender, result in wide gaps in stroke care disfavoring women in South-and-Southeast Asia. Future directions to improve equity of care should target improved public awareness of stroke among women, policies cognizant of the existing gender-disparity with the intent of making them viable for women, and equal representation of women in stroke research to better understand gender-based differences in stroke. [ABSTRACT FROM AUTHOR]