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Objectives: Blunt abdominal trauma is a common cause of emergency department admission. Computed tomography (CT) scanning is the gold standard method for identifying intra-abdominal injuries in patients experiencing blunt trauma, especially those with high-energy trauma. Although the diagnostic accuracy of this imaging technique is very high, patient admission and prolonged observation protocols are still common practices worldwide. We aimed to evaluate the incidence of intra-abdominal injury in hemodynamically stable patients with high-energy blunt trauma and a normal abdominal CT scan at a Level-1 Trauma Center in Colombia, South America, to assess the relevance of a prolonged observation period. Methods: We performed a retrospective study of patients admitted to the emergency department for blunt trauma between 2021 and 2022. All consecutive patients with high-energy mechanisms of trauma and a normal CT scan at admission were included. Our primary outcomes were the incidence of intra-abdominal injury identified during a 24-hour observation period or hospital stay, ICU admission, and death. Results: We included 480 patients who met the inclusion criteria. The median age was 33 (IQR 25.5, 47), and 74.2% were male. The most common mechanisms of injury were motor vehicle accidents (64.2%), falls from height (26%), and falls from bikes (3.1%). A total of 99.2% of patients had a Revised Trauma Score of 8. Only 1 patient (0.2%) (95% CI: 0.01–1.16) presented with an abdominal injury during the observation period. No ICU admissions or deaths were reported. Conclusion: The incidence of intra-abdominal injury in patients with hemodynamically stable blunt trauma and a negative abdominal CT scan is extremely low, and prolonged observation may not be justified in these patients. [ABSTRACT FROM AUTHOR]

Predicting coastal change depends upon our knowledge of postglacial relative sea-level variability, partly controlled by glacio-isostatic responses to ice-sheet melting. Here, we reconstruct the postglacial relative sea-level changes along the Caribbean and Pacific coasts of northwestern South America by numerically solving the sea-level equation with two scenarios of mantle viscosity: global standard average and high viscosity. Our results with the standard model (applicable to the Pacific coast) agree with earlier studies by indicating a mid-Northgrippian high stand of ~2 m. The high-viscosity simulation (relevant to the Caribbean coast) shows that the transition from far- to intermediate-field influence of the Laurentide Ice Sheet occurs between Manzanillo del Mar and the Gulf of Morrosquillo. South of this location, the Colombian Caribbean coast has exhibited a still stand with a nearly constant Holocene relative sea level. By analyzing our simulations considering sea-level indicators, we argue that tectonics is more prominent than previously assumed, especially along the Caribbean coast. This influence prevents a simplified view of regional relative sea-level changes on the northwestern South American coast. [ABSTRACT FROM AUTHOR]

In this paper I analyse how the gradual reduction of research funds in Colombia can interrupt a key process in the generation of solutions to global urban problems. I draw on a bibliometric analysis to show that research funding flowing from North to South has created collaborations between researchers from North and South that have led to a better and more comprehensive understanding of the challenges facing cities around the world. To conclude, I propose four options to counteract these trends towards lower research funding. [ABSTRACT FROM AUTHOR]

Global commitments prioritize protection of wildlife and improvements to human wellbeing. Local disconnects in these commitments are rarely acknowledged—or their implications assessed—preventing the development of effective solutions. National and international efforts to protect marine mammals along South America's west coast have contributed to species recovery, but also to conflict between sea lions and small‐scale fisheries. To understand the concerns ultimately motivating this conflict, we assessed how 301 coastal small‐scale fishers perceive their interactions with South American sea lions (Otaria flavescens). We then reviewed the terrestrial human–wildlife literature to identify potential management solutions to resolve the conflict. We find that fishers are chiefly concerned with increases in sea lion populations, perceive that sea lion interactions have significantly increased over the past 80 years, and report sea lion‐driven catch and income losses of ≥26%. We propose solutions to manage conflict that are sensitive to heterogeneity among fisher groups. [ABSTRACT FROM AUTHOR]

It is largely unknown how South America's Andean forests affect the global carbon cycle, and thus regulate climate change. Here, we measure aboveground carbon dynamics over the past two decades in 119 monitoring plots spanning a range of >3000 m elevation across the subtropical and tropical Andes. Our results show that Andean forests act as strong sinks for aboveground carbon (0.67 ± 0.08 Mg C ha−1 y−1) and have a high potential to serve as future carbon refuges. Aboveground carbon dynamics of Andean forests are driven by abiotic and biotic factors, such as climate and size-dependent mortality of trees. The increasing aboveground carbon stocks offset the estimated C emissions due to deforestation between 2003 and 2014, resulting in a net total uptake of 0.027 Pg C y−1. Reducing deforestation will increase Andean aboveground carbon stocks, facilitate upward species migrations, and allow for recovery of biomass losses due to climate change. Here, the authors investigate the aboveground carbon sink efficiency of Andean forests. The study shows the high potential of these forests to serve as future carbon refuges, and urges to reduce deforestation and increase restoration. [ABSTRACT FROM AUTHOR]

This paper explores the relationships between proactive environmental strategy (PES) and internationalization in emerging markets multinationals from Latin America (Multilatinas). Drawing on the resource‐based view and institutional theory and using a sample of 86 listed firms during the period 2013–2017, we find that Multilatinas with higher tiers of PES are associated with higher degrees of geographic international diversification. Because adopting PES is directly conditioned by institutional pressures to comply with stakeholders' regulations and expectations, Multilatinas that implement advanced PES will be able to achieve a higher level of international presence in foreign markets. Our results also reveal that board independence positively moderates the relationship between PES and geographic international diversification. Specifically, board independence provides Multilatinas with the opportunity to integrate valuable knowledge and expertise and thus to take advantage of implementing advanced PES to achieve even greater levels of internationalization. This study expands understanding of how environmental strategies influence internationalization of firms in the Latin American business context. [ABSTRACT FROM AUTHOR]

Copyright of Estudios Gerenciales is the property of Universidad ICESI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Memorias is the property of Fundacion Universidad del Norte and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Colombiana de Psiquiatria is the property of Asociacion Colombiana de Psiquiatria and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The species ofPassifloraare widely used in folk medicine as mild sedatives and tranquilizers.P. alataandP. quadrangularisare distributed throughout South America, with widespread occurrence in Brazil and Colombia. Due to the difficulty in making a botanical distinction between these species, especially in the absence of flowers and fruits, the use of chemical markers for these plants offer an alternative method of identification. This work describes the isolation and identification of the major flavonoids and saponins from the leaves ofP. alataandP. quadrangularis, as well as rapid and efficient HPLC-DAD methods for comparison of these compounds in both species. Vitexin derivatives are proposed as chemical markers in the identification ofP. alataandP. quadrangularisand the detection of adulterations in raw material. [ABSTRACT FROM AUTHOR]

Background: Marine allopatric speciation involves interplay between intrinsic organismal properties and extrinsic factors. However, the relative contribution of each depends on the taxon under study and its geographic context. Utilizing sea catfishes in the Cathorops mapale species group, this study tests the hypothesis that both reproductive strategies conferring limited dispersal opportunities and an apparent geomorphologic barrier in the Southern Caribbean have promoted speciation in this group from a little studied area of the world. Methodology/Principal Findings: Mitochondrial gene sequences were obtained from representatives of the Cathorops mapale species group across its distributional range from Colombia to Venezuela. Morphometric and meristic analyses were also done to assess morphologic variation. Along a ∼2000 km transect, two major lineages, Cathorops sp. and C. mapale, were identified by levels of genetic differentiation, phylogenetic reconstructions, and morphological analyses. The lineages are separated by ∼150 km at the Santa Marta Massif (SMM) in Colombia. The northward displacement of the SMM into the Caribbean in the early Pleistocene altered the geomorphology of the continental margin, ultimately disrupting the natural habitat of C. mapale. The estimated ∼0.86 my divergence of the lineages from a common ancestor coincides with the timing of the SMM displacement at ∼0.78 my. Main Conclusions/Significance: Results presented here support the hypothesis that organismal properties as well as extrinsic factors lead to diversification of the Cathorops mapale group along the northern coast of South America. While a lack of pelagic larval stages and ecological specialization are forces impacting this process, the identification of the SMM as contributing to allopatric speciation in marine organisms adds to the list of recognized barriers in the Caribbean. Comparative examination of additional Southern Caribbean taxa, particularly those with varying life history traits and dispersal capabilities, will determine the extent by which the SMM has influenced marine phylogeography in the region. [ABSTRACT FROM AUTHOR]

The world's greatest terrestrial stores of biodiversity and carbon are found in the forests of northern South America, where large-scale biogeographic patterns and processes have recently begun to be described. Seven of the nine countries with territory in the Amazon basin and the Guiana shield have carried out large-scale forest inventories, but such massive data sets have been little exploited by tropical plant ecologists. Although forest inventories often lack the species-level identifications favoured by tropical plant ecologists, their consistency of measurement and vast spatial coverage make them ideally suited for numerical analyses at large scales, and a valuable resource to describe the still poorly understood spatial variation of biomass, diversity, community composition and forest functioning across the South American tropics. Here we show, by using the seven forest inventories complemented with trait and inventory data collected elsewhere, two dominant gradients in tree composition and function across the Amazon, one paralleling a major gradient in soil fertility and the other paralleling a gradient in dry season length. The data set also indicates that the dominance of Fabaceae in the Guiana shield is not necessarily the result of root adaptations to poor soils (nodulation or ectomycorrhizal associations) but perhaps also the result of their remarkably high seed mass there as a potential adaptation to low rates of disturbance. [ABSTRACT FROM AUTHOR]

Abstract: We describe a traverse across the Cordillera Real and sub-Andean Zone of Ecuador, poorly known areas with very little detailed mapping and very little age control. The spine of the Cordillera comprises deeply eroded Triassic and Jurassic plutons, the roots of a major arc, emplaced into probable Palaeozoic pelites and metamorphosed volcanic rocks. The W flank comprises a Jurassic (?) submarine basaltic–andesitic volcanic sequence, which grades up into mixed Jurassic/Cretaceous volcanic and sedimentary rocks of the Inter-Andean Valley. The sub-Andean Zone, on the E flank of the Cordillera, comprises a newly recognized Cretaceous basin of cleaved mudrocks, quartz arenites and limestones. East of the syndepositional Cosanga Fault, the Cretaceous basin thins into a condensed sequence that is indistinguishable from the rocks of the adjacent hydrocarbon-bearing Oriente Basin. The principal penetrative deformation of the Cordillera Real was probably latest Cretaceous/Palaeocene. It telescoped the magmatic belts, but shortening was largely partitioned into the pelites between plutons. The plutons suffered inhomogenous deformation; some portions completely escaped tectonism. The pelites conserve two foliations. The earliest comprises slaty cleavage formed under low- or sub-greenschist conditions. The later is a strong schistosity defined by new mica growth. It largely transposed and obliterated the first. Both foliations may have developed during a single progressive deformation. We find inappropriate recent terrane models for the Cordillera Real and sub-Andean Zone of Ecuador. Instead we find remarkable similarities from one side of the Cordillera to the other, including a common structural history. In place of sutures, we find mostly intrusive contacts between major plutons and pelites. Triassic to Cretaceous events occurred on the autochthonous western edge of the Archaean Guyana Shield. The latest Cretaceous–Paleocene deformation is interpreted as the progressive collision of an oceanic terrane(s) with the South American continent. Young fault movements have subsequently juxtaposed different structural levels through the Cordillera Real orogen. [Copyright &y& Elsevier]

Despite nearly a century of research and accounting for the highest disease burden of any parasitic disease in the Western Hemisphere, Chagas disease (CD) is still a challenging diagnosis, primarily due to its poor recognition outside of Latin America. Although initially considered endemic to Central and South America, globalization, urbanization, and increased migration have spread the disease worldwide in the last few years, making it a significant public health threat. The international medical community's apparent lack of interest in this disease that was previously thought to be geographically restricted has delayed research on the complex host–parasite relationship that determines myocardial involvement and its differential behavior from other forms of cardiomyopathy, particularly regarding treatment strategies. Multiple cellular and molecular mechanisms that contribute to degenerative, inflammatory, and fibrotic myocardial responses have been identified and warrant further research to expand the therapeutic arsenal and impact the high burden attributed to CD. Altogether, cardiac dysautonomia, microvascular disturbances, parasite-mediated myocardial damage, and chronic immune-mediated injury are responsible for the disease's clinical manifestations, ranging from asymptomatic disease to severe cardiac and gastrointestinal involvement. It is crucial for healthcare workers to better understand CD transmission and disease dynamics, including its behavior on both its acute and chronic phases, to make adequate and evidence-based decisions regarding the disease. This review aims to summarize the most recent information on the epidemiology, pathogenesis, clinical presentation, diagnosis, screening, and treatment of CD, emphasizing on Chagasic cardiomyopathy's (Ch-CMP) clinical presentation and pathobiological mechanisms leading to sudden cardiac death. [ABSTRACT FROM AUTHOR]

• Parasites increase LC3 in cardiac cells and peritoneal macrophages in vitro. • Autophagy induction reduces parasite internalization in macrophages. • Starved non-professional phagocytes impair parasite intracellular life cycle. • Host autophagy induction decreases infection in vitro , in ATG5-dependent manner. Trypanosoma cruzi causes Chagas disease, a neglected illness that affects millions of people worldwide, especially in Latin America. The balance between biochemical pathways triggered by the parasite and host cells response will ultimately define the progression of a life-threatening disease, justifying the efforts to understand cellular mechanisms for infection restrain. In this interaction, parasite and host cells are affected by different physiological responses as autophagy modulation, which could be under intense cellular stress, such as nutrient deprivation, hormone depletion, or infection. Autophagy is a constitutive pathway that leads to degradation of macromolecules and cellular structures and may induce cell death. In Trypanosoma cruzi infection, the relevance of host autophagy is controversial regarding in vitro parasite intracellular life cycle. In the present study, we evaluated host cell autophagy during T. cruzi infection in phagocytic and non-professional phagocytic cells. We described that the presence of the parasite increased the number of LC3 puncta, a marker for autophagy, in cardiac cells and peritoneal macrophages in vitro. The induction of host autophagy decreased infection in macrophages in early and late time-periods. We suggest that starved phagocytic cells reduced internalization, also confirmed by inert particles and dead trypomastigotes. Whereas, in cardiac cells, starvation-induced autophagy decreased lipid droplets and infection in later time-point, by reducing parasite differentiation/proliferation. In ATG5 knockout MEF cells, we confirmed our hypothesis of autophagy machinery activation during parasite internalization, increasing infection. Our data suggest that host autophagy downregulates T. cruzi infection through impairing parasite intracellular life cycle, reducing the infection in primary culture cells. [ABSTRACT FROM AUTHOR]

Canine distemper virus (CDV) is considered a reemerging disease-causing agent in domestic dogs because it presents high divergence among circulating strains worldwide. In Colombia, the South America-3 and South America/North America-4 lineages co-circulate in domestic dogs, both in the Medellin metropolitan area. In this paper, two full CDV genomes from each viral lineage circulating in Medellin were sequenced; we explored the phylogenetic relationship with the available genome sequences; we described the presence of CDV mutations in the South America-3 and South America/North America-4 lineages associated with adaptation to human cells and a crossing of the species barrier and pathogenicity; and we established the evolutionary rates and time of the closest common ancestor for each gene and characterized the presentation of multiple genomic sites by positive selection. [ABSTRACT FROM AUTHOR]

Blood safety has been of paramount concern worldwide over the last decades, and Latin America and Mexico are no exception. Factors of utmost importance include the use of highly efficient screening tests and the encouragement of voluntary donation. This review summarizes the current situation in Latin America and particularly in Mexico with respect to these key issues. Except for some specific regions, there is a lack of progress of voluntary donation in Mexico compared with other Latin American countries. A more efficient voluntary donation system could provide donors with lower prevalence of infectious agents such as human immunodeficiency, hepatitis B, and hepatitis C viruses. In Latin America, and specifically in countries such as Argentina, Brazil and Nicaragua, voluntary donation and blood safety are strongly encouraged. However, to date, in Mexico there has not been a specific blood safety project because of fragmentation of the health system model with structural differences among organisations. Although national policies are established to grant health coverages in Mexico, blood safety is still limited and outdated because of oversights in technical fields and regulations. Individual molecular biological tests for donor screening have recently been incorporated into the Mexican national regulations. Although the routine use of these tests as part of effective donor screening is still not compulsory, it is enabling a progressive improvement of blood safety. [ABSTRACT FROM AUTHOR]

Highlights: [•] BFRs and UV-F levels were comparable to those reported in other regions of the world. [•] The contamination was greater in Colombian sites. [•] Contribution of BFRs was higher than that of UV-F for almost all sediments. [•] Deca-BDE was the formulation used in Colombia, whereas Penta-BDE was also applied in Chile. [•] DBDPE was detected only in Chilean samples. [Copyright &y& Elsevier]

Our knowledge about the structure and function of Andean forests at regional scales remains limited. Current initiatives to study forests over continental or global scales still have important geographical gaps, particularly in regions such as the tropical and subtropical Andes. In this study, we assessed patterns of structure and tree species diversity along ~ 4000 km of latitude and ~ 4000 m of elevation range in Andean forests. We used the Andean Forest Network (Red de Bosques Andinos, https://redbosques.condesan.org/) database which, at present, includes 491 forest plots (totaling 156.3 ha, ranging from 0.01 to 6 ha) representing a total of 86,964 identified tree stems ≥ 10 cm diameter at breast height belonging to 2341 identified species, 584 genera and 133 botanical families. Tree stem density and basal area increases with elevation while species richness decreases. Stem density and species richness both decrease with latitude. Subtropical forests have distinct tree species composition compared to those in the tropical region. In addition, floristic similarity of subtropical plots is between 13 to 16% while similarity between tropical forest plots is between 3% to 9%. Overall, plots ~ 0.5-ha or larger may be preferred for describing patterns at regional scales in order to avoid plot size effects. We highlight the need to promote collaboration and capacity building among researchers in the Andean region (i.e., South-South cooperation) in order to generate and synthesize information at regional scale., Competing Interests: The authors have declared that no competing interests exist.