Search

This chapter outlines mobile phone use among African (particularly South African) adolescents. With an estimated 350 million active mobile phone subscriptions, improving network infrastructure, low-cost Internet-ready handsets, innovative programs and applications, mobiles in Africa, and their increasingly younger, increasingly poorer, and increasingly savvy users have the potential to act as conduits for local and regional socially just change. This broad-based connectedness not only provides access to information, but also, and crucially, connects individuals and their social, intellectual, and financial capital. It may represent a powerful, transformative shift in a region where access to similar technologies was historically limited to a privileged few. In order to best leverage these developments and opportunities to promote socially just change, I argue that future mobile-based programs or initiatives in the region should be based in both contemporary developmental systems theory as well as current, popular mobile applications and services. (Contains 1 table and 16 notes.)

Background: The introduction of C-C chemokine receptor type-5 (CCR5) antagonists as antiretroviral therapy has led to the need to study HIV co-receptor tropism in different HIV-1 subtypes and geographical locations. This study was undertaken to evaluate HIV-1 co-receptor tropism in the developing world where non-B subtypes predominate, in order to assess the therapeutic and prophylactic potential of CCR5 antagonists in these regions. Methods: HIV-1-infected patients were recruited into this prospective, cross-sectional, epidemiologic study from HIV clinics in South Africa, Uganda and India. Patients were infected with subtypes C (South Africa, India) or A or D (Uganda). HIV-1 subtype and co-receptor tropism were determined and analyzed with disease characteristics, including viral load and CD4+ and CD8+ T cell counts. Results: CCR5-tropic (R5) HIV-1 was detected in 96% of treatment-naïve (TN) and treatment-experienced (TE) patients in India, 71% of TE South African patients, and 86% (subtype A/A1) and 71% (subtype D) of TN and TE Ugandan patients. Dual/mixed-tropic HIV-1 was found in 4% of Indian, 25% of South African and 13% (subtype A/ A1) and 29% (subtype D) of Ugandan patients. Prior antiretroviral treatment was associated with decreased R5 tropism; however, this decrease was less in subtype C from India (TE: 94%, TN: 97%) than in subtypes A (TE: 59%; TN: 91%) and D (TE: 30%; TN: 79%). R5 virus infection in all three subtypes correlated with higher CD4+ count. Conclusions: R5 HIV-1 was predominant in TN individuals with HIV-1 subtypes C, A, and D and TE individuals with subtypes C and A. Higher CD4+ count correlated with R5 prevalence, while treatment experience was associated with increased non-R5 infection in all subtypes. [ABSTRACT FROM AUTHOR]