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This article focuses on chronic bullous disease of childhood. Chronic bullous disease of childhood (CBDC) is a rare autoimmune disease characterized clinically by sub-epidermal bullae and annular lesions with a predilection for the perineum. Most published series are from Europe and North America; there are also case reports from Jamaica, Africa, Singapore and Japan. In Great Britain. and Sri Lanka the populations sampled were very similar in number. However, only data from Durban in South Africa was available. Minor differences in the age at presentation of CBDC were seen and a female predominance was found only in the African series. Linear basement membrane zone staining for immunoglobulin A was demonstrated on direct immunofluorescence in all patients.