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Glacier response patterns at the catchment scale are highly heterogeneous and defined by a complex interplay of various dynamics and surface factors. Previous studies have explained heterogeneous responses in qualitative ways but quantitative assessment is lacking yet where an intrazone homogeneous climate assumption can be valid. Hence, in the current study, the reason for heterogeneous mass balance has been explained in quantitative methods using a multiple linear regression model in the Sikkim Himalayan region. At first, the topographical parameters are selected from previously published studies, then the most significant topographical and geomorphological parameters are selected with backward stepwise subset selection methods. Finally, the contributions of selected parameters are calculated by least square methods. The results show that, the magnitude of mass balance lies between −0.003±0.24 to −1.029±0.24 m.w.e.a−1 between 2000 and 2020 in the Sikkim Himalaya region. Also, the study shows that, out of the terminus type of the glacier, glacier area, debris cover, ice-mixed debris, slope, aspect, mean elevation, and snout elevation of the glaciers, only the terminus type and mean elevation of the glacier are significantly altering the glacier mass balance in the Sikkim Himalayan region. Mathematically, the mass loss is approximately 0.40 m.w.e.a−1 higher in the lake-terminating glaciers compared to the land-terminating glaciers in the same elevation zone. On the other hand, a thousand meters mean elevation drop is associated with 0.179 m.w.e.a−1 of mass loss despite the terminus type of the glaciers. In the current study, the model using the terminus type of the glaciers and the mean elevation of the glaciers explains 76% of fluctuation of mass balance in the Sikkim Himalayan region. [ABSTRACT FROM AUTHOR]