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Reducing exploration risks and realizing scientific prospecting always have been frontier fields and research hotspots in the world of mineral exploration, the theory and method of ore prospecting prediction for exploration area is the valid channel to deal with this problem. Using this method, a geological model of ore prospecting can be established by combining the internal (geochemical behavior of elements) and external (types of geological processes) control factors for mineralization. The main components of the prospecting prediction model include geological bodies related to mineralization, metallogenetic structure planes and mineralization characteristics. Together with the results of special geological mapping, geophysical and geochemical exploration on large scale, orebodies have been located by synthetic information and explored by drilling. Case studies of the Lala copper deposit in Sichuan, Muhu-Maerkantu manganese ore deposit in Xinjiang and Aonaodaba tin-polymetallic deposit in Inner Mongolia, illustrate the effective application of this method in ore prospecting prediction. [ABSTRACT FROM AUTHOR]